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Literature summary for 3.5.1.98 extracted from

  • Mal, A.; Sturniolo, M.; Schiltz, R.L.; Ghosh, M.K.; Harter, M.L.
    A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic program (2001), EMBO J., 20, 1739-1753.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
FLAG-tagged protein, expression in C2 or 10T1/2 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
H141A not able to deacetylate MyoD transcription factor or to repress MyoD-mediated transcription in vivo Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetyl-lysine-MyoD + H2O Homo sapiens transcription factor MyoD, its activity is co-dependent on isoform HDAC1 and transcriptional co-activator P/CAF acetate + MyoD
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-lysine-MyoD + H2O transcription factor MyoD, its activity is co-dependent on isoform HDAC1 and transcriptional co-activator P/CAF Homo sapiens acetate + MyoD
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N-acetyl-lysine-MyoD + H2O transcrition factor MyoD Homo sapiens acetate + MyoD
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Subunits

Subunits Comment Organism
More in undifferentiatied muscle cells, isoform HDAC1 associates with transcription factor MyoD resulting in silencing of MyoD-dependent transcription of endogenous p21 as well as muscle-specific genes Homo sapiens