Protein Variants | Comment | Organism |
---|---|---|
additional information | the strain PAO1-DELTApvd is shown to be more virulent than the wild-type strain, confirming the role of PvdQ as a virulence-reducing agent | Pseudomonas aeruginosa PAO1 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa PAO1 | - |
the virulence of Pseudomonas aeruginosa PAO1 is analyzed in a Caenorhabditis elegans infection model | - |
Purification (Comment) | Organism |
---|---|
a two-step purification protocol, anion exchange chromatography and hydrophobic interaction chromatography | Pseudomonas aeruginosa PAO1 |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | in the Caenorhabditis elegans infection model it is observed that larval stage 1 to 3 benefit much more from the protection by PvdQ than larval stage 4 worms | Pseudomonas aeruginosa PAO1 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-3-oxododecanoyl-L-homoserine lactone + H2O | - |
Pseudomonas aeruginosa PAO1 | L-homoserine lactone + 3-oxododecanoic acid | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acyl-homoserine lactone acylase | - |
Pseudomonas aeruginosa PAO1 |
AHL acylase | - |
Pseudomonas aeruginosa PAO1 |
PvdQ | - |
Pseudomonas aeruginosa PAO1 |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Pseudomonas aeruginosa PAO1 |
General Information | Comment | Organism |
---|---|---|
physiological function | PvdQ functions as a quorum quencher in vitro. Purified PvdQ is added to Caenorhabditis elegans worms infected with wild-type PAO1 and this results in reduced pathogenicity and increases the life span of the nematodes. PvdQ might be a strong candidate for antibacterial therapy against Pseudomonas infections | Pseudomonas aeruginosa PAO1 |