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Literature summary for 3.5.1.97 extracted from

  • Papaioannou, E.; Wahjudi, M.; Nadal-Jimenez, P.; Koch, G.; Setroikromo, R.; Quax, W.J.
    Quorum-quenching acylase reduces the virulence of Pseudomonas aeruginosa in a Caenorhabditis elegans infection model (2009), Antimicrob. Agents Chemother., 53, 4891-4897.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information the strain PAO1-DELTApvd is shown to be more virulent than the wild-type strain, confirming the role of PvdQ as a virulence-reducing agent Pseudomonas aeruginosa PAO1

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa PAO1
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the virulence of Pseudomonas aeruginosa PAO1 is analyzed in a Caenorhabditis elegans infection model
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Purification (Commentary)

Purification (Comment) Organism
a two-step purification protocol, anion exchange chromatography and hydrophobic interaction chromatography Pseudomonas aeruginosa PAO1

Source Tissue

Source Tissue Comment Organism Textmining
additional information in the Caenorhabditis elegans infection model it is observed that larval stage 1 to 3 benefit much more from the protection by PvdQ than larval stage 4 worms Pseudomonas aeruginosa PAO1
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-3-oxododecanoyl-L-homoserine lactone + H2O
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Pseudomonas aeruginosa PAO1 L-homoserine lactone + 3-oxododecanoic acid
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Synonyms

Synonyms Comment Organism
acyl-homoserine lactone acylase
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Pseudomonas aeruginosa PAO1
AHL acylase
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Pseudomonas aeruginosa PAO1
PvdQ
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Pseudomonas aeruginosa PAO1

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Pseudomonas aeruginosa PAO1

General Information

General Information Comment Organism
physiological function PvdQ functions as a quorum quencher in vitro. Purified PvdQ is added to Caenorhabditis elegans worms infected with wild-type PAO1 and this results in reduced pathogenicity and increases the life span of the nematodes. PvdQ might be a strong candidate for antibacterial therapy against Pseudomonas infections Pseudomonas aeruginosa PAO1