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Literature summary for 3.5.1.9 extracted from

  • Gonzalez Esquivel, D.; Ramirez-Ortega, D.; Pineda, B.; Castro, N.; Rios, C.; Perez de la Cruz, V.
    Kynurenine pathway metabolites and enzymes involved in redox reactions (2017), Neuropharmacology, 112, 331-345 .
    View publication on PubMed
Search for more literature for 3.5.1.9

Activating Compound

Activating Compound Comment Organism Structure
arginine
-
 Oncorhynchus mykiss
ascorbic acid
-
 Oncorhynchus mykiss
L-tryptophan
-
 Oncorhynchus mykiss
o-aminophenol activates Rattus norvegicus
o-toluidine activates Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
3-hydroxykynurenine potent inhibitor Oncorhynchus mykiss
Ag+
-
 Rattus norvegicus
anthranilic acid
-
 Rattus norvegicus
Co2+ moderate inhibitor Oncorhynchus mykiss
Cu2+ moderate inhibitor Oncorhynchus mykiss
CuSO4
-
 Rattus norvegicus
diethyl-(4-nitrophenyl)-phosphate
-
 Rattus norvegicus
Hg2+ potent inhibitor Oncorhynchus mykiss
Hg2+
-
 Rattus norvegicus
KCN
-
 Neurospora crassa
L-kynurenine potent inhibitor Oncorhynchus mykiss
L-kynurenine
-
 Rattus norvegicus
Mn2+ potent inhibitor Oncorhynchus mykiss
additional information no inhibition by p-chloromercuribenzoate Neurospora crassa
additional information activity is not affected by Mn2+, Mg2+, Zn2+, Fe2+, Fe3+, ascorbic acid, cysteine, glutathione, p-chloromercuribenzoate, EDTA, KCN, K3Fe(CN)6, Na2S2O6 and sodium formate Rattus norvegicus
N-bromosuccinimide
-
 Rattus norvegicus
Na-Metaarsenite
-
 Rattus norvegicus
Na2S2O4
-
 Rattus norvegicus
NaAsO2
-
 Rattus norvegicus
NaF
-
 Rattus norvegicus
NaHSO4
-
 Rattus norvegicus
Zn2+ potent inhibitor Oncorhynchus mykiss

Organism

Organism UniProt Comment Textmining
Equus caballus F6WFA7
-
-
Neurospora crassa F5HBR2
-
-
Neurospora crassa ATCC 24698 F5HBR2
-
-
Oncorhynchus mykiss
-
-
-
Rattus norvegicus M0RC77
-
-
Sus scrofa A0A287B5F1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
brain
-
 Equus caballus
-
liver
-
 Rattus norvegicus
-
liver
-
 Equus caballus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-formyl-L-kynurenine + H2O
-
 Oncorhynchus mykiss formate + L-kynurenine
-
 ?
N-formyl-L-kynurenine + H2O
-
 Rattus norvegicus formate + L-kynurenine
-
 ?
N-formyl-L-kynurenine + H2O
-
 Equus caballus formate + L-kynurenine
-
 ?
N-formyl-L-kynurenine + H2O
-
 Sus scrofa formate + L-kynurenine
-
 ?
N-formyl-L-kynurenine + H2O
-
 Neurospora crassa formate + L-kynurenine
-
 ?
N-formyl-L-kynurenine + H2O
-
 Neurospora crassa ATCC 24698 formate + L-kynurenine
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5 9
-
 Rattus norvegicus