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Literature summary for 3.5.1.9 extracted from
- Structural requirements of organophosphorus insecticides (OPI) to inhibit chicken yolk sac membrane kynurenine formamidase related to OPI teratogenesis (2013), Environ. Toxicol. Pharmacol., 35, 200-206.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Coumaphos | - |
Gallus gallus |  |
| diazinon | - |
Gallus gallus | |
| dichlorvos | - |
Gallus gallus | |
| dicrotophos | - |
Gallus gallus | |
| Dimethoate | - |
Gallus gallus | |
| ethylpirimiphos | - |
Gallus gallus | |
| etrimfos | - |
Gallus gallus | |
| leptophos | - |
Gallus gallus | |
| malathion | - |
Gallus gallus | |
| methamidophos | - |
Gallus gallus | |
| methylchlorpyriphos | - |
Gallus gallus | |
| methylparathion | - |
Gallus gallus | |
| methylpirimiphos | - |
Gallus gallus | |
| mevinphos | - |
Gallus gallus | |
| Monocrotophos | - |
Gallus gallus | |
| additional information | determination and analysis of organophosphorus insecticides structural requirements to inhibit in ovo chicken embryo yolk sac membrane kynurenine formamidase, inhibition mechanism, plnED50 values, overview. The dominant electrostatic interactions are localized at nitrogen-1, nitrogen-3, nitrogen of 2-amino substituent of the pyrimidinyl of pyrimidinyl phosphorothioates, and the oxygen of crotonamide carbonyl in crotonamide phosphates. Bulkiness of the substituents at carbon-2 and carbon-6 of the pyrimidinyls and/or N-substituents and carbon-3 substituents of crotonamides are the steric structural components that contribute to in ovo inhibition of the enzyme | Gallus gallus | |
| parathion | - |
Gallus gallus | |
| phorate | - |
Gallus gallus | |
| Phosphamidon | - |
Gallus gallus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | E1C2H6 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| vitelline membrane | - |
Gallus gallus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| kynurenine formamidase | - |
Gallus gallus |
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