Literature summary for 3.5.1.88 extracted from

Kwon, Y.J.; Sohn, M.J.; Kim, C.J.; Koshino, H.; Kim, W.G.
Flavimycins A and B, dimeric 1,3-dihydroisobenzofurans with peptide deformylase inhibitory activity from Aspergillus flavipes (2012), J. Nat. Prod., 75, 271-274.

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Inhibitors

Inhibitors	Comment	Organism	Structure
flavimycin A	a dimeric 1,3-dihydroisobenzofuran, isolated from cultures of Aspergillus flavipes, structure analysis by NMR and mass spectrometry, the inhibitor exists as epimeric mixture at C-1 through fast hemiacetal-aldehyde tautomerism. The compound has antibacterial activity against Staphylococcus aureus including MRSA, with MIC values of 0.032-0.064 mg/mL	Staphylococcus aureus
flavimycin B	a dimeric 1,3-dihydroisobenzofuran, isolated from cultures of Aspergillus flavipes, structure analysis by NMR and mass spectrometry, the inhibitor exists as epimeric mixture at C-1 through fast hemiacetal-aldehyde tautomerism. The compound has antibacterial activity against Staphylococcus aureus including MRSA, with MIC values of 0.032-0.064 mg/mL	Staphylococcus aureus

Organism

Organism	UniProt	Comment	Textmining
Staphylococcus aureus	-	-	-

Synonyms

Synonyms	Comment	Organism
PDF	-	Staphylococcus aureus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0358	-	pH and temperature not specified in the publication	Staphylococcus aureus	flavimycin A
0.1001	-	pH and temperature not specified in the publication	Staphylococcus aureus	flavimycin B

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Release 2023.1 (January 2023)