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Literature summary for 3.5.1.88 extracted from

  • Boularot, A.; Giglione, C.; Petit, S.; Duroc, Y.; Alves de Sousa, R.; Larue, V.; Cresteil, T.; Dardel, F.; Artaud, I.; Meinnel, T.
    Discovery and refinement of a new structural class of potent peptide deformylase inhibitors (2007), J. Med. Chem., 50, 10-20.
    View publication on PubMed
Search for more literature for 3.5.1.88

Inhibitors

Inhibitors Comment Organism Structure
(1-hydroxyaminomethyl-2-phenylethyl)carbamic acid tert-butyl ester AtPDF2 Arabidopsis thaliana
(1-hydroxycarbamoylmethyl-2-phenylethyl)carbamic acid tert-butyl ester AtPDF2 Arabidopsis thaliana
1-(5-bromo-1H-indol-3-yl)-3-hydroxypropan-2-one AtPDF2 Arabidopsis thaliana
2-(4-fluoro-1H-indol-3-yl)-N-hydroxyacetamide AtPDF2 Arabidopsis thaliana
2-(4-fluoro-1H-indol-3-yl)-N-hydroxyacetamide
-
 Homo sapiens
2-(5-bromo-1H-indol-3-yl)-N-hydroxyacetamide
-
 Arabidopsis thaliana
2-(5-bromo-1H-indol-3-yl)-N-hydroxyacetamide MIC is 0.0031 mg/ml Bacillus subtilis
2-(5-bromo-1H-indol-3-yl)-N-hydroxyacetamide MIC is 0.006 mg/ml Escherichia coli
2-(5-bromo-1H-indol-3-yl)-N-hydroxyacetamide
-
 Homo sapiens
2-(5-bromo-2-methyl-1H-indolyl)-N-hydroxyacetamide AtPDF2 Arabidopsis thaliana
2-(5-bromo-2-methyl-1H-indolyl)-N-hydroxyacetamide
-
 Homo sapiens
2-(5-chloro-1H-indol-3-yl)-N-hydroxyacetamide AtPDF2 Arabidopsis thaliana
2-(5-chloro-1H-indol-3-yl)-N-hydroxyacetamide MIC is 0.013 mg/ml Bacillus subtilis
2-(5-chloro-1H-indol-3-yl)-N-hydroxyacetamide MIC is 0.025 mg/ml Escherichia coli
2-(5-chloro-1H-indol-3-yl)-N-hydroxyacetamide
-
 Homo sapiens
2-(5-fluoro-1H-indol-3-yl)-N-hydroxyacetamide AtPDF2 Arabidopsis thaliana
2-(5-fluoro-1H-indol-3-yl)-N-hydroxyacetamide MIC is 0.027 mg/ml Bacillus subtilis
2-(5-fluoro-1H-indol-3-yl)-N-hydroxyacetamide MIC is 0.04 mg/ml Escherichia coli
2-(5-methoxy-1H-indol-3-yl)-N-hydroxyacetamide AtPDF2 Arabidopsis thaliana
2-(6-bromo-1H-indol-3-yl)-N-hydroxyacetamide AtPDF2 Arabidopsis thaliana
2-(6-bromo-1H-indol-3-yl)-N-hydroxyacetamide
-
 Homo sapiens
2-(indol-3-yl)-N-hydroxyacetamide AtPDF2 Arabidopsis thaliana
2-(indol-3-yl)-N-hydroxyacetamide MIC is 0.16 mg/ml Bacillus subtilis
2-(indol-3-yl)-N-hydroxyacetamide MIC is 0.115 mg/ml Escherichia coli
3-(3-acetylsulfanyl-2-oxopropyl)indole-1-carboxylic acid benzyl ester AtPDF2 Arabidopsis thaliana
3-carboxymethylindol-1-carboxylic acid benzyl ester AtPDF2 Arabidopsis thaliana
5-bromo-3-hydroxycarbamoylmethylindole-1-carboxylic acid benzyl ester AtPDF2 Arabidopsis thaliana
5-bromo-3-hydroxycarbamoylmethylindole-1-carboxylic acid benzyl ester MIC is 0.016 mg/ml Bacillus subtilis
5-bromo-3-hydroxycarbamoylmethylindole-1-carboxylic acid benzyl ester MIC is 0.12 mg/ml Escherichia coli
actinonin AtPDF2 Arabidopsis thaliana
actinonin MIC is 0.0013 mg/ml Bacillus subtilis
actinonin MIC is 0.034 mg/ml Escherichia coli
actinonin
-
 Homo sapiens
N-((5-bromo-2-methyl-1(phenylsulfonyl)-1H-indol-3-yl)methyl) hydroxylamine AtPDF2 Arabidopsis thaliana
N-(1-benzenesulfonyl-5-bromo-2-methyl-1H-indol-3-ylmethyl)-N-hydroxyformamide AtPDF2 Arabidopsis thaliana
N-(1-benzenesulfonyl-5-bromo-2-methyl-1H-indol-3-ylmethyl)-N-hydroxyformamide MIC is 0.035 mg/ml Bacillus subtilis
N-(1-benzenesulfonyl-5-bromo-2-methyl-1H-indol-3-ylmethyl)-N-hydroxyformamide MIC is 0.065 mg/ml Escherichia coli
N-(1-benzenesulfonyl-5-bromo-2-methyl-1H-indol-3-ylmethyl)-N-hydroxyformamide
-
 Homo sapiens
N-[2-(5-bromo-2-methyl-1H-indole-3-yl)methyl]hydroxylamine AtPDF2 Arabidopsis thaliana
thioacetic acid S-[3-(5-bromo-1H-indol-3-yl)-2-oxopropyl] ester AtPDF2 Arabidopsis thaliana
thioacetic acid S-[3-(indol-3-yl)-2-oxopropyl] ester AtPDF2 Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Arabidopsis thaliana 5739
-

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-
Arabidopsis thaliana Q9FUZ2 precursor
-
Arabidopsis thaliana Q9FV53 precursor
-
Bacillus subtilis
-
-
-
Escherichia coli
-
-
-
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
AtPDF1A
-
 Arabidopsis thaliana
AtPDF1B
-
 Arabidopsis thaliana
AtPDF2
-
 Arabidopsis thaliana

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00001
-
 actinonin
-
 Arabidopsis thaliana
0.000013
-
 2-(5-bromo-1H-indol-3-yl)-N-hydroxyacetamide
-
 Arabidopsis thaliana
0.000015
-
 2-(5-chloro-1H-indol-3-yl)-N-hydroxyacetamide AtPDF2 Arabidopsis thaliana
0.000018
-
 5-bromo-3-hydroxycarbamoylmethylindole-1-carboxylic acid benzyl ester AtPDF2 Arabidopsis thaliana
0.00002
-
 2-(5-fluoro-1H-indol-3-yl)-N-hydroxyacetamide AtPDF2 Arabidopsis thaliana
0.000025
-
 N-(1-benzenesulfonyl-5-bromo-2-methyl-1H-indol-3-ylmethyl)-N-hydroxyformamide AtPDF2 Arabidopsis thaliana
0.000027
-
 actinonin
-
 Arabidopsis thaliana
0.000027
-
 5-bromo-3-hydroxycarbamoylmethylindole-1-carboxylic acid benzyl ester
-
 Arabidopsis thaliana
0.00003
-
 N-(1-benzenesulfonyl-5-bromo-2-methyl-1H-indol-3-ylmethyl)-N-hydroxyformamide
-
 Arabidopsis thaliana
0.00003
-
 2-(6-bromo-1H-indol-3-yl)-N-hydroxyacetamide AtPDF2 Arabidopsis thaliana
0.000035
-
 2-(5-bromo-1H-indol-3-yl)-N-hydroxyacetamide
-
 Arabidopsis thaliana
0.000044
-
 (1-hydroxycarbamoylmethyl-2-phenylethyl)carbamic acid tert-butyl ester
-
 Arabidopsis thaliana
0.00005
-
 (1-hydroxycarbamoylmethyl-2-phenylethyl)carbamic acid tert-butyl ester
-
 Arabidopsis thaliana
0.00008
-
 2-(5-chloro-1H-indol-3-yl)-N-hydroxyacetamide
-
 Arabidopsis thaliana
0.0001
-
 2-(4-fluoro-1H-indol-3-yl)-N-hydroxyacetamide AtPDF2 Arabidopsis thaliana
0.0001
-
 2-(5-bromo-2-methyl-1H-indolyl)-N-hydroxyacetamide AtPDF2 Arabidopsis thaliana
0.00016
-
 2-(5-fluoro-1H-indol-3-yl)-N-hydroxyacetamide
-
 Arabidopsis thaliana
0.00021
-
 2-(6-bromo-1H-indol-3-yl)-N-hydroxyacetamide
-
 Arabidopsis thaliana
0.0003
-
 (1-hydroxycarbamoylmethyl-2-phenylethyl)carbamic acid tert-butyl ester AtPDF2 Arabidopsis thaliana
0.0003
-
 2-(indol-3-yl)-N-hydroxyacetamide AtPDF2 Arabidopsis thaliana
0.00033
-
 2-(5-methoxy-1H-indol-3-yl)-N-hydroxyacetamide AtPDF2 Arabidopsis thaliana
0.0004
-
 (1-hydroxycarbamoylmethyl-2-phenylethyl)carbamic acid tert-butyl ester AtPDF2 Arabidopsis thaliana
0.0004
-
 N-((5-bromo-2-methyl-1(phenylsulfonyl)-1H-indol-3-yl)methyl) hydroxylamine AtPDF2 Arabidopsis thaliana
0.0006
-
 actinonin
-
 Homo sapiens
0.001
-
 N-[2-(5-bromo-2-methyl-1H-indole-3-yl)methyl]hydroxylamine AtPDF2 Arabidopsis thaliana
0.0014
-
 2-(indol-3-yl)-N-hydroxyacetamide
-
 Arabidopsis thaliana
0.002
-
 2-(4-fluoro-1H-indol-3-yl)-N-hydroxyacetamide
-
 Arabidopsis thaliana
0.003
-
 2-(5-bromo-2-methyl-1H-indolyl)-N-hydroxyacetamide
-
 Arabidopsis thaliana
0.006
-
 N-((5-bromo-2-methyl-1(phenylsulfonyl)-1H-indol-3-yl)methyl) hydroxylamine
-
 Arabidopsis thaliana
0.009
-
 2-(5-methoxy-1H-indol-3-yl)-N-hydroxyacetamide
-
 Arabidopsis thaliana
0.014
-
 5-bromo-3-hydroxycarbamoylmethylindole-1-carboxylic acid benzyl ester
-
 Arabidopsis thaliana
0.035
-
 N-(1-benzenesulfonyl-5-bromo-2-methyl-1H-indol-3-ylmethyl)-N-hydroxyformamide
-
 Arabidopsis thaliana
0.05
-
 N-[2-(5-bromo-2-methyl-1H-indole-3-yl)methyl]hydroxylamine
-
 Arabidopsis thaliana
0.052
-
 (1-hydroxyaminomethyl-2-phenylethyl)carbamic acid tert-butyl ester
-
 Arabidopsis thaliana
0.083
-
 (1-hydroxycarbamoylmethyl-2-phenylethyl)carbamic acid tert-butyl ester
-
 Arabidopsis thaliana
0.1
-
 3-(3-acetylsulfanyl-2-oxopropyl)indole-1-carboxylic acid benzyl ester AtPDF2 Arabidopsis thaliana
0.11
-
 (1-hydroxyaminomethyl-2-phenylethyl)carbamic acid tert-butyl ester AtPDF2 Arabidopsis thaliana
0.12
-
 thioacetic acid S-[3-(5-bromo-1H-indol-3-yl)-2-oxopropyl] ester
-
 Arabidopsis thaliana
0.12
-
 thioacetic acid S-[3-(5-bromo-1H-indol-3-yl)-2-oxopropyl] ester AtPDF2 Arabidopsis thaliana
0.13
-
 2-(5-bromo-1H-indol-3-yl)-N-hydroxyacetamide
-
 Arabidopsis thaliana
0.15
-
 (1-hydroxycarbamoylmethyl-2-phenylethyl)carbamic acid tert-butyl ester
-
 Arabidopsis thaliana
0.17
-
 thioacetic acid S-[3-(5-bromo-1H-indol-3-yl)-2-oxopropyl] ester
-
 Arabidopsis thaliana
0.2
-
 N-(1-benzenesulfonyl-5-bromo-2-methyl-1H-indol-3-ylmethyl)-N-hydroxyformamide
-
 Homo sapiens
0.2
-
 thioacetic acid S-[3-(indol-3-yl)-2-oxopropyl] ester
-
 Arabidopsis thaliana
0.2
-
 thioacetic acid S-[3-(indol-3-yl)-2-oxopropyl] ester AtPDF2 Arabidopsis thaliana
0.25
-
 2-(5-chloro-1H-indol-3-yl)-N-hydroxyacetamide
-
 Arabidopsis thaliana
0.25
-
 2-(6-bromo-1H-indol-3-yl)-N-hydroxyacetamide
-
 Homo sapiens
0.25
-
 2-(6-bromo-1H-indol-3-yl)-N-hydroxyacetamide
-
 Arabidopsis thaliana
0.25
-
 1-(5-bromo-1H-indol-3-yl)-3-hydroxypropan-2-one AtPDF2 Arabidopsis thaliana
0.28
-
 3-carboxymethylindol-1-carboxylic acid benzyl ester AtPDF2 Arabidopsis thaliana
0.3
-
 3-carboxymethylindol-1-carboxylic acid benzyl ester
-
 Arabidopsis thaliana
0.35
-
 3-(3-acetylsulfanyl-2-oxopropyl)indole-1-carboxylic acid benzyl ester
-
 Arabidopsis thaliana
0.36
-
 2-(5-bromo-1H-indol-3-yl)-N-hydroxyacetamide
-
 Homo sapiens
0.45
-
 2-(5-bromo-2-methyl-1H-indolyl)-N-hydroxyacetamide
-
 Homo sapiens
0.45
-
 2-(5-bromo-2-methyl-1H-indolyl)-N-hydroxyacetamide
-
 Arabidopsis thaliana
0.5
-
 3-(3-acetylsulfanyl-2-oxopropyl)indole-1-carboxylic acid benzyl ester
-
 Arabidopsis thaliana
0.5
-
 N-((5-bromo-2-methyl-1(phenylsulfonyl)-1H-indol-3-yl)methyl) hydroxylamine
-
 Arabidopsis thaliana
0.56
-
 1-(5-bromo-1H-indol-3-yl)-3-hydroxypropan-2-one
-
 Arabidopsis thaliana
0.6
-
 2-(5-chloro-1H-indol-3-yl)-N-hydroxyacetamide
-
 Homo sapiens
0.7
-
 2-(5-fluoro-1H-indol-3-yl)-N-hydroxyacetamide
-
 Arabidopsis thaliana
0.7
-
 2-(4-fluoro-1H-indol-3-yl)-N-hydroxyacetamide
-
 Homo sapiens
0.79
-
 1-(5-bromo-1H-indol-3-yl)-3-hydroxypropan-2-one
-
 Arabidopsis thaliana