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Literature summary for 3.5.1.88 extracted from

  • Hu, X.; Nguyen, K.T.; Jiang, V.C.; Lofland, D.; Moser, H.E.; Pei, D.
    Macrocyclic inhibitors for peptide deformylase: a structure-activity relationship study of the ring size (2004), J. Med. Chem., 47, 4941-4949.
    View publication on PubMed
Search for more literature for 3.5.1.88

Application

Application Comment Organism
medicine antibacterial activity against clinically significant Gram-positive and Gram-negative pathogens Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
(2R)-N-[(1S)-1-(dimethylcarbamoyl)-2,2-dimethylpropyl]-2-[[formyl(hydroxy)amino]methyl]hexanamide
-
 Escherichia coli
(2R)-N-[(1S)-5-amino-1-(hexylcarbamoyl)pentyl]-2-[[formyl(hydroxy)amino]methyl]heptanamide
-
 Escherichia coli
N-(3-tert-butyl-2,5-dioxo-1,4-diaza-cycloheptadec-6-yl)-methyl-N-hydroxy-formamide
-
 Escherichia coli
N-(3-tert-butyl-2,5-dioxo-1,4-diaza-cyclohexadec-6-yl)-methyl-N-hydroxy-formamide
-
 Escherichia coli
N-(3-tert-butyl-2,5-dioxo-1,4-diaza-cycloicos-6-yl)-methyl-N-hydroxy-formamide
-
 Escherichia coli
N-(3-tert-butyl-2,5-dioxo-1,4-diaza-cyclopentadec-6-yl)-methyl-N-hydroxy-formamide
-
 Escherichia coli
N-(3-tert-butyl-2,5-dioxo-1,4-diaza-cyclotridec-6-yl)-methyl-N-hydroxy-formamide
-
 Escherichia coli
N-[3-(4-acetamidobutyl)-2,5-dioxo-1,4-diaza-cyclopentadec-6-yl]methyl-N-hydroxy-formamide
-
 Escherichia coli
N-[3-(4-aminobutyl)-2,5-dioxo-1,4-diazacycloicos-6-yl]methyl-N-hydroxyformamide
-
 Escherichia coli
N-[3-(4-aminobutyl)-2,5-dioxo-1,4-diazacyclopentadec-6-yl]methyl-N-hydroxyformamide
-
 Escherichia coli
N2-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-phenyl-L-lysinamide
-
 Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
formyl-L-methionyl peptide + H2O Escherichia coli
-
 formate + methionyl peptide
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli P0A6K3
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
formyl-L-methionyl peptide + H2O
-
 Escherichia coli formate + methionyl peptide
-
 ?

Synonyms

Synonyms Comment Organism
PDF
-
 Escherichia coli
peptide deformylase
-
 Escherichia coli

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 room temperature, AAP PDF inhibition assay Escherichia coli
25
-
 room temperature, DPPI PDF inhibition assay Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 AAP PDF inhibition assay Escherichia coli
7
-
 DPPI PDF inhibition assay Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000011
-
 (2R)-N-[(1S)-1-(dimethylcarbamoyl)-2,2-dimethylpropyl]-2-[[formyl(hydroxy)amino]methyl]hexanamide DPPI assay Escherichia coli
0.000023
-
 N2-[(2R)-2-[[formyl(hydroxy)amino]methyl]hexanoyl]-N-phenyl-L-lysinamide DPPI assay Escherichia coli
0.000063
-
 N-(3-tert-butyl-2,5-dioxo-1,4-diaza-cyclotridec-6-yl)-methyl-N-hydroxy-formamide DPPI assay Escherichia coli
0.000074
-
 (2R)-N-[(1S)-5-amino-1-(hexylcarbamoyl)pentyl]-2-[[formyl(hydroxy)amino]methyl]heptanamide DPPI assay Escherichia coli
0.000077
-
 N-(3-tert-butyl-2,5-dioxo-1,4-diaza-cycloheptadec-6-yl)-methyl-N-hydroxy-formamide DPPI assay Escherichia coli
0.000092
-
 N-[3-(4-aminobutyl)-2,5-dioxo-1,4-diazacyclopentadec-6-yl]methyl-N-hydroxyformamide DPPI assay Escherichia coli
0.000096
-
 N-(3-tert-butyl-2,5-dioxo-1,4-diaza-cyclohexadec-6-yl)-methyl-N-hydroxy-formamide DPPI assay Escherichia coli
0.000109
-
 N-(3-tert-butyl-2,5-dioxo-1,4-diaza-cyclopentadec-6-yl)-methyl-N-hydroxy-formamide DPPI assay Escherichia coli
0.000258
-
 N-[3-(4-aminobutyl)-2,5-dioxo-1,4-diazacycloicos-6-yl]methyl-N-hydroxyformamide DPPI assay Escherichia coli
0.00071
-
 N-[3-(4-acetamidobutyl)-2,5-dioxo-1,4-diaza-cyclopentadec-6-yl]methyl-N-hydroxy-formamide DPPI assay Escherichia coli
0.0021
-
 N-(3-tert-butyl-2,5-dioxo-1,4-diaza-cycloicos-6-yl)-methyl-N-hydroxy-formamide DPPI assay Escherichia coli