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Literature summary for 3.5.1.88 extracted from

  • Molteni, V.; He, X.; Nabakka, J.; Yang, K.; Kreusch, A.; Gordon, P.; Bursulaya, B.; Warner, I.; Shin, T.; Biorac, T.; Ryder, N.S.; Goldberg, R.; Doughty, J.; He, Y.
    Identification of novel potent bicyclic peptide deformylase inhibitors (2004), Bioorg. Med. Chem. Lett., 14, 1477-1481.
    View publication on PubMed

Application

Application Comment Organism
medicine peptide deformylase has been considered an attractive target for antibacterial chemotherapy Staphylococcus aureus

Crystallization (Commentary)

Crystallization (Comment) Organism
Ni-peptide deformylase from Pseudomonas aeruguinosa was co-crystallized with inhibitor Staphylococcus aureus

Inhibitors

Inhibitors Comment Organism Structure
actinonin
-
Staphylococcus aureus
analogues of actinonin 35 different compounds were synthesized and compared to the inhibitory activity of actinonin Staphylococcus aureus

Metals/Ions

Metals/Ions Comment Organism Structure
Ni
-
Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
formyl-L-methionyl peptide + H2O Staphylococcus aureus
-
formate + methionyl peptide
-
?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
formyl-L-methionyl peptide + H2O
-
Staphylococcus aureus formate + methionyl peptide
-
?

Synonyms

Synonyms Comment Organism
PDF
-
Staphylococcus aureus
peptide deformylase
-
Staphylococcus aureus