Literature summary for 3.5.1.88 extracted from

Apfel, C.; Banner, D.W.; Bur, D.; Dietz, M.; Hirata, T.; Hubschwerlen, C.; Locher, H.; Page, M.G.P.; Pirson, W.; Rosse, G.; Specklin, J.L.
Hydroxyamic acid derivates as potent peptide deformylase inhibitors and antibacterial agents (2000), J. Med. Chem., 43, 2324-2331.

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Application

Application	Comment	Organism
medicine	possible target for new broad spectrum antimicrobial agents	Escherichia coli

Inhibitors

Inhibitors	Comment	Organism	Structure
(RS)- and (SR)-3-[(RS)-benzenesulfinyl]heptanoic acid hydroxyamide	mixture of both components, IC50: 0.0001 mM, possible antimicrobial agent	Escherichia coli
(RS)-3-(phenylsulfonyl)heptanoic acid hydroxyamide	IC50: 0.035 micro molar, possible antimicrobial agent	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cell culture	-	Escherichia coli	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-formyl-Met-Ala-Ser + H2O	-	Escherichia coli	formate + Met-Ala-Ser	-	?

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000035	-	IC50: 0.035 micro molar, possible antimicrobial agent	Escherichia coli	(RS)-3-(phenylsulfonyl)heptanoic acid hydroxyamide
0.0001	-	mixture of both components, IC50: 0.0001 mM, possible antimicrobial agent	Escherichia coli	(RS)- and (SR)-3-[(RS)-benzenesulfinyl]heptanoic acid hydroxyamide

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Release 2023.1 (January 2023)