Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3,5-dichloro-4-nitropyridine | AM11095, synthetis of the specific brain permeable NAAA inhibitor, a slowly reversible NAAA inhibitor | Homo sapiens | |
3,5-dichloro-4-nitropyridine | AM11095, synthetis is of the specific brain permeable NAAA inhibitor, a slowly reversible NAAA inhibitor | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
lysosome | - |
Rattus norvegicus | 5764 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-oleoylethanolamide + H2O | Homo sapiens | - |
oleate + ethanolamine | - |
? | |
N-oleoylethanolamide + H2O | Rattus norvegicus | - |
oleate + ethanolamine | - |
? | |
N-oleoylethanolamide + H2O | Rattus norvegicus Sprague-Dawley | - |
oleate + ethanolamine | - |
? | |
N-palmitoylethanolamide + H2O | Homo sapiens | - |
palmitate + ethanolamine | - |
? | |
N-palmitoylethanolamide + H2O | Rattus norvegicus | - |
palmitate + ethanolamine | - |
? | |
N-palmitoylethanolamide + H2O | Rattus norvegicus Sprague-Dawley | - |
palmitate + ethanolamine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q02083 | - |
- |
Rattus norvegicus | Q6P7S1 | - |
- |
Rattus norvegicus Sprague-Dawley | Q6P7S1 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
brain | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-oleoylethanolamide + H2O | - |
Homo sapiens | oleate + ethanolamine | - |
? | |
N-oleoylethanolamide + H2O | - |
Rattus norvegicus | oleate + ethanolamine | - |
? | |
N-oleoylethanolamide + H2O | - |
Rattus norvegicus Sprague-Dawley | oleate + ethanolamine | - |
? | |
N-palmitoylethanolamide + H2O | - |
Homo sapiens | palmitate + ethanolamine | - |
? | |
N-palmitoylethanolamide + H2O | - |
Rattus norvegicus | palmitate + ethanolamine | - |
? | |
N-palmitoylethanolamide + H2O | - |
Rattus norvegicus Sprague-Dawley | palmitate + ethanolamine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
N-acylethanolamine acid amidase | - |
Homo sapiens |
N-acylethanolamine acid amidase | - |
Rattus norvegicus |
NAAA | - |
Homo sapiens |
NAAA | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00002 | - |
pH and temperature not specified in the publication | Homo sapiens | 3,5-dichloro-4-nitropyridine |
General Information | Comment | Organism |
---|---|---|
malfunction | effects of pretreatment with the NAAA inhibitor AM11095 on nicotine-related effects in the rat mesolimbic dopamine system, phenotype, detailed overview | Rattus norvegicus |