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Literature summary for 3.5.1.60 extracted from
- Identification of highly potent N-acylethanolamine acid amidase (NAAA) inhibitors optimization of the terminal phenyl moiety of oxazolidone derivatives (2017), Eur. J. Med. Chem., 139, 214-221 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-(4-phenoxybenzoyl)-1,3-oxazolidin-2-one | - |
Rattus norvegicus |  |
| 3-(6-phenylhexanoyl)-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[4-(3-chlorophenoxy)benzoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[4-(3-methylphenoxy)benzoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[4-(4-hydroxyphenoxy)benzoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[4-(4-methylphenoxy)benzoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[4-(cyclohexyloxy)benzoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[4-(cyclopentyloxy)benzoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[4-(pentyloxy)benzoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[4-[(4-hydroxycyclohexyl)oxy]benzoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[4-[(oxan-4-yl)oxy]benzoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[4-[(pentan-3-yl)oxy]benzoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[6-(2-chlorophenyl)hexanoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[6-(2-hydroxyphenyl)hexanoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[6-(2-methylphenyl)hexanoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[6-(3,4-dimethylphenyl)hexanoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[6-(3-aminophenyl)hexanoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[6-(3-bromophenyl)hexanoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[6-(3-chloro-4-fluorophenyl)hexanoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[6-(3-chloro-4-hydroxyphenyl)hexanoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[6-(3-chlorophenyl)hexanoyl]-1,3-oxazolidin-2-one | interaction mechanism with NAAA by a Yonetani-Theorell analysis | Rattus norvegicus | |
| 3-[6-(3-fluoro-4-hydroxyphenyl)hexanoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[6-(3-hydroxyphenyl)hexanoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[6-(3-iodophenyl)hexanoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[6-(3-methoxyphenyl)hexanoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[6-(3-methylphenyl)hexanoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[6-(4-aminophenyl)hexanoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[6-(4-bromophenyl)hexanoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[6-(4-chlorophenyl)hexanoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[6-(4-hydroxyphenyl)hexanoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[6-(4-iodophenyl)hexanoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[6-(4-methoxyphenyl)hexanoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[6-(4-methylphenyl)hexanoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[6-oxo-6-(2-oxo-1,3-oxazolidin-3-yl)hexyl]benzamide | - |
Rattus norvegicus | |
| 3-[6-oxo-6-(2-oxo-1,3-oxazolidin-3-yl)hexyl]benzoic acid | - |
Rattus norvegicus | |
| 3-[6-[3-(hydroxymethyl)phenyl]hexanoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[6-[3-(methylsulfanyl)phenyl]hexanoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[6-[3-(trifluoromethyl)phenyl]hexanoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[6-[4-(hydroxymethyl)phenyl]hexanoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[6-[4-(methylsulfanyl)phenyl]hexanoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 3-[6-[4-(trifluoromethyl)phenyl]hexanoyl]-1,3-oxazolidin-2-one | - |
Rattus norvegicus | |
| 4-[6-oxo-6-(2-oxo-1,3-oxazolidin-3-yl)hexyl]benzamide | - |
Rattus norvegicus | |
| 4-[6-oxo-6-(2-oxo-1,3-oxazolidin-3-yl)hexyl]benzoic acid | - |
Rattus norvegicus | |
| 5-phenylpentyl-N-[(2S,3R)-2-methyl-4-oxo-oxetan-3-yl]carbamate | ARN077 | Rattus norvegicus | |
| additional information | structure-activity relationship of oxazolidone derivatives, inhibitory mechanism, overview | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| lysosome | - |
Rattus norvegicus | 5764 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | Q5KTC7 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| N-acylethanolamine acid amidase | - |
Rattus norvegicus |
| NAAA | - |
Rattus norvegicus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| additional information | - |
above 20 mM, pH and temperature not specified in the publication | Rattus norvegicus | 3-[4-(4-hydroxyphenoxy)benzoyl]-1,3-oxazolidin-2-one | |
| additional information | - |
above 20 mM, pH and temperature not specified in the publication | Rattus norvegicus | 3-[6-(2-chlorophenyl)hexanoyl]-1,3-oxazolidin-2-one | |
| additional information | - |
above 20 mM, pH and temperature not specified in the publication | Rattus norvegicus | 3-[6-(2-hydroxyphenyl)hexanoyl]-1,3-oxazolidin-2-one | |
| additional information | - |
above 20 mM, pH and temperature not specified in the publication | Rattus norvegicus | 3-[6-(2-methylphenyl)hexanoyl]-1,3-oxazolidin-2-one | |
| additional information | - |
above 20 mM, pH and temperature not specified in the publication | Rattus norvegicus | 3-[6-(3,4-dimethylphenyl)hexanoyl]-1,3-oxazolidin-2-one | |
| additional information | - |
above 20 mM, pH and temperature not specified in the publication | Rattus norvegicus | 3-[6-(3-aminophenyl)hexanoyl]-1,3-oxazolidin-2-one | |
| additional information | - |
above 20 mM, pH and temperature not specified in the publication | Rattus norvegicus | 3-[6-(3-chloro-4-hydroxyphenyl)hexanoyl]-1,3-oxazolidin-2-one | |
| additional information | - |
above 20 mM, pH and temperature not specified in the publication | Rattus norvegicus | 3-[6-(4-iodophenyl)hexanoyl]-1,3-oxazolidin-2-one | |
| additional information | - |
above 20 mM, pH and temperature not specified in the publication | Rattus norvegicus | 3-[6-(4-methoxyphenyl)hexanoyl]-1,3-oxazolidin-2-one | |
| additional information | - |
above 20 mM, pH and temperature not specified in the publication | Rattus norvegicus | 3-[6-oxo-6-(2-oxo-1,3-oxazolidin-3-yl)hexyl]benzamide | |
| additional information | - |
above 20 mM, pH and temperature not specified in the publication | Rattus norvegicus | 3-[6-oxo-6-(2-oxo-1,3-oxazolidin-3-yl)hexyl]benzoic acid | |
| additional information | - |
above 20 mM, pH and temperature not specified in the publication | Rattus norvegicus | 3-[6-[3-(hydroxymethyl)phenyl]hexanoyl]-1,3-oxazolidin-2-one | |
| additional information | - |
above 20 mM, pH and temperature not specified in the publication | Rattus norvegicus | 3-[6-[4-(methylsulfanyl)phenyl]hexanoyl]-1,3-oxazolidin-2-one | |
| additional information | - |
above 20 mM, pH and temperature not specified in the publication | Rattus norvegicus | 4-[6-oxo-6-(2-oxo-1,3-oxazolidin-3-yl)hexyl]benzamide | |
| additional information | - |
above 20 mM, pH and temperature not specified in the publication | Rattus norvegicus | 4-[6-oxo-6-(2-oxo-1,3-oxazolidin-3-yl)hexyl]benzoic acid | |
| 0.000009 | - |
above, pH and temperature not specified in the publication | Rattus norvegicus | 3-[6-(3-chlorophenyl)hexanoyl]-1,3-oxazolidin-2-one | |
| 0.000026 | - |
above, pH and temperature not specified in the publication | Rattus norvegicus | 3-[6-(3-chloro-4-fluorophenyl)hexanoyl]-1,3-oxazolidin-2-one | |
| 0.000058 | - |
above, pH and temperature not specified in the publication | Rattus norvegicus | 3-[6-[3-(trifluoromethyl)phenyl]hexanoyl]-1,3-oxazolidin-2-one | |
| 0.000061 | - |
above, pH and temperature not specified in the publication | Rattus norvegicus | 3-[6-(4-hydroxyphenyl)hexanoyl]-1,3-oxazolidin-2-one | |
| 0.000092 | - |
above, pH and temperature not specified in the publication | Rattus norvegicus | 3-[4-(cyclohexyloxy)benzoyl]-1,3-oxazolidin-2-one | |
| 0.00012 | - |
above, pH and temperature not specified in the publication | Rattus norvegicus | 3-[4-(cyclopentyloxy)benzoyl]-1,3-oxazolidin-2-one | |
| 0.00016 | - |
above, pH and temperature not specified in the publication | Rattus norvegicus | 3-[6-(3-fluoro-4-hydroxyphenyl)hexanoyl]-1,3-oxazolidin-2-one | |
| 0.00019 | - |
above, pH and temperature not specified in the publication | Rattus norvegicus | 3-[6-[4-(hydroxymethyl)phenyl]hexanoyl]-1,3-oxazolidin-2-one | |
| 0.00021 | - |
above, pH and temperature not specified in the publication | Rattus norvegicus | 3-[4-[(4-hydroxycyclohexyl)oxy]benzoyl]-1,3-oxazolidin-2-one | |
| 0.00027 | - |
above, pH and temperature not specified in the publication | Rattus norvegicus | 3-(6-phenylhexanoyl)-1,3-oxazolidin-2-one | |
| 0.00033 | - |
above, pH and temperature not specified in the publication | Rattus norvegicus | 3-[4-[(oxan-4-yl)oxy]benzoyl]-1,3-oxazolidin-2-one | |
| 0.00035 | - |
above, pH and temperature not specified in the publication | Rattus norvegicus | 3-[6-(3-methylphenyl)hexanoyl]-1,3-oxazolidin-2-one | |
| 0.00043 | - |
above, pH and temperature not specified in the publication | Rattus norvegicus | 3-[6-(3-bromophenyl)hexanoyl]-1,3-oxazolidin-2-one | |
| 0.00048 | - |
above, pH and temperature not specified in the publication | Rattus norvegicus | 3-[4-[(pentan-3-yl)oxy]benzoyl]-1,3-oxazolidin-2-one | |
| 0.00064 | - |
above, pH and temperature not specified in the publication | Rattus norvegicus | 3-[4-(pentyloxy)benzoyl]-1,3-oxazolidin-2-one | |
| 0.00068 | - |
above, pH and temperature not specified in the publication | Rattus norvegicus | 3-(4-phenoxybenzoyl)-1,3-oxazolidin-2-one | |
| 0.00104 | - |
above, pH and temperature not specified in the publication | Rattus norvegicus | 3-[6-[4-(trifluoromethyl)phenyl]hexanoyl]-1,3-oxazolidin-2-one | |
| 0.00134 | - |
above, pH and temperature not specified in the publication | Rattus norvegicus | 3-[4-[(pentan-3-yl)oxy]benzoyl]-1,3-oxazolidin-2-one | |
| 0.00312 | - |
above, pH and temperature not specified in the publication | Rattus norvegicus | 3-[6-(3-iodophenyl)hexanoyl]-1,3-oxazolidin-2-one | |
| 0.0046 | - |
above, pH and temperature not specified in the publication | Rattus norvegicus | 3-[6-(4-chlorophenyl)hexanoyl]-1,3-oxazolidin-2-one | |
| 0.00521 | - |
above, pH and temperature not specified in the publication | Rattus norvegicus | 3-[4-(3-methylphenoxy)benzoyl]-1,3-oxazolidin-2-one | |
| 0.0064 | - |
above, pH and temperature not specified in the publication | Rattus norvegicus | 3-[4-(4-methylphenoxy)benzoyl]-1,3-oxazolidin-2-one | |
| 0.00774 | - |
above, pH and temperature not specified in the publication | Rattus norvegicus | 3-[4-(3-chlorophenoxy)benzoyl]-1,3-oxazolidin-2-one | |
| 0.00851 | - |
above, pH and temperature not specified in the publication | Rattus norvegicus | 3-[6-(4-bromophenyl)hexanoyl]-1,3-oxazolidin-2-one | |
| 0.00864 | - |
above, pH and temperature not specified in the publication | Rattus norvegicus | 3-[6-(3-hydroxyphenyl)hexanoyl]-1,3-oxazolidin-2-one | |
| 0.0128 | - |
above, pH and temperature not specified in the publication | Rattus norvegicus | 3-[6-[3-(methylsulfanyl)phenyl]hexanoyl]-1,3-oxazolidin-2-one | |
| 0.0157 | - |
above, pH and temperature not specified in the publication | Rattus norvegicus | 3-[6-(4-aminophenyl)hexanoyl]-1,3-oxazolidin-2-one | |
| 0.0163 | - |
above, pH and temperature not specified in the publication | Rattus norvegicus | 3-[6-(3-methoxyphenyl)hexanoyl]-1,3-oxazolidin-2-one | |
| 0.44 | - |
above, pH and temperature not specified in the publication | Rattus norvegicus | 3-[6-(4-methylphenyl)hexanoyl]-1,3-oxazolidin-2-one | |
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