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Literature summary for 3.5.1.52 extracted from
- The cytoplasmic peptide N-glycanase (Ngly1) - basic science encounters a human genetic disorder (2015), J. Biochem., 157, 23-34 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene DDB0189828, sequence comparisons and phylogenetic analysis | Dictyostelium discoideum |
| gene Ncpng1, sequence comparisons and phylogenetic analysis | Neurospora crassa |
| gene NGLY1, sequence comparisons and phylogenetic analysis | Mus musculus |
| gene NGLY1, sequence comparisons and phylogenetic analysis | Homo sapiens |
| gene PNG1, sequence comparisons and phylogenetic analysis | Caenorhabditis elegans |
| gene PNG1, sequence comparisons and phylogenetic analysis | Saccharomyces cerevisiae |
| gene PNG1, sequence comparisons and phylogenetic analysis | Arabidopsis thaliana |
| gene PNG1, sequence comparisons and phylogenetic analysis | Drosophila melanogaster |
| gene PNG1, sequence comparisons and phylogenetic analysis | Schizosaccharomyces pombe |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Z-VAD-fmk | - |
Arabidopsis thaliana |  |
| Z-VAD-fmk | - |
Caenorhabditis elegans | |
| Z-VAD-fmk | - |
Dictyostelium discoideum | |
| Z-VAD-fmk | - |
Homo sapiens | |
| Z-VAD-fmk | - |
Mus musculus | |
| Z-VAD-fmk | - |
Oryzias latipes | |
| Z-VAD-fmk | - |
Saccharomyces cerevisiae | |
| Z-VAD-fmk | - |
Schizosaccharomyces pombe | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Oryzias latipes | 5737 | - |
| cytoplasm | - |
Caenorhabditis elegans | 5737 | - |
| cytoplasm | - |
Saccharomyces cerevisiae | 5737 | - |
| cytoplasm | - |
Mus musculus | 5737 | - |
| cytoplasm | - |
Dictyostelium discoideum | 5737 | - |
| cytoplasm | - |
Arabidopsis thaliana | 5737 | - |
| cytoplasm | - |
Drosophila melanogaster | 5737 | - |
| cytoplasm | - |
Homo sapiens | 5737 | - |
| cytoplasm | - |
Schizosaccharomyces pombe | 5737 | - |
| membrane | minor distribution of Ngly1 in the membrane fraction | Mus musculus | 16020 | - |
| membrane | minor distribution of Ngly1 in the membrane fraction | Homo sapiens | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | dependent on | Oryzias latipes | |
| Zn2+ | dependent on | Caenorhabditis elegans | |
| Zn2+ | dependent on | Saccharomyces cerevisiae | |
| Zn2+ | dependent on | Mus musculus | |
| Zn2+ | dependent on | Dictyostelium discoideum | |
| Zn2+ | dependent on | Neurospora crassa | |
| Zn2+ | dependent on | Arabidopsis thaliana | |
| Zn2+ | dependent on | Homo sapiens | |
| Zn2+ | dependent on | Schizosaccharomyces pombe | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Saccharomyces cerevisiae | protein-protein interaction involving the cytoplasmic peptide:N-glycanase with DNA repair-related protein Rad23 | ? | - |
? | |
| additional information | Mus musculus | the cytoplasmic PNGase in mammals is able to bind to p97/VCP/Cdc48, a key ATPases accosiated with diverse cellular activities (AAA) adenosine triphosphate (ATPase) for the ERAD pathway, as well as other ERAD or ubiquitinx02proteasome pathway-related proteins, some of which are intrinsic membrane proteins | ? | - |
? | |
| additional information | Homo sapiens | the cytoplasmic PNGase in mammals is able to bind to p97/VCP/Cdc48, a key ATPases accosiated with diverse cellular activities (AAA) adenosine triphosphate (ATPase) for the ERAD pathway, as well as other ERAD or ubiquitinx02proteasome pathway-related proteins, some of which are intrinsic membrane proteins | ? | - |
? | |
| additional information | Saccharomyces cerevisiae ATCC 204508 | protein-protein interaction involving the cytoplasmic peptide:N-glycanase with DNA repair-related protein Rad23 | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | Q9FGY9 | - |
- |
| Caenorhabditis elegans | Q9TW67 | - |
- |
| Dictyostelium discoideum | Q55FC8 | - |
- |
| Drosophila melanogaster | Q7KRR5 | - |
- |
| Homo sapiens | Q96IV0 | - |
- |
| Mus musculus | Q9JI78 | - |
- |
| Neurospora crassa | D1MY48 | - |
- |
| Oryzias latipes | - |
medaka fish | - |
| Saccharomyces cerevisiae | Q02890 | - |
- |
| Saccharomyces cerevisiae ATCC 204508 | Q02890 | - |
- |
| Schizosaccharomyces pombe | O74739 | - |
- |
| Schizosaccharomyces pombe 972 | O74739 | - |
- |
| Schizosaccharomyces pombe ATCC 24843 | O74739 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | protein-protein interaction involving the cytoplasmic peptide:N-glycanase with DNA repair-related protein Rad23 | Saccharomyces cerevisiae | ? | - |
? | |
| additional information | the cytoplasmic PNGase in mammals is able to bind to p97/VCP/Cdc48, a key ATPases accosiated with diverse cellular activities (AAA) adenosine triphosphate (ATPase) for the ERAD pathway, as well as other ERAD or ubiquitinx02proteasome pathway-related proteins, some of which are intrinsic membrane proteins | Mus musculus | ? | - |
? | |
| additional information | the cytoplasmic PNGase in mammals is able to bind to p97/VCP/Cdc48, a key ATPases accosiated with diverse cellular activities (AAA) adenosine triphosphate (ATPase) for the ERAD pathway, as well as other ERAD or ubiquitinx02proteasome pathway-related proteins, some of which are intrinsic membrane proteins | Homo sapiens | ? | - |
? | |
| additional information | protein-protein interaction involving the cytoplasmic peptide:N-glycanase with DNA repair-related protein Rad23 | Saccharomyces cerevisiae ATCC 204508 | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DDB0189828 | - |
Dictyostelium discoideum |
| Ncpng1 | - |
Neurospora crassa |
| Ngly1 | - |
Oryzias latipes |
| Ngly1 | - |
Caenorhabditis elegans |
| Ngly1 | - |
Saccharomyces cerevisiae |
| Ngly1 | - |
Mus musculus |
| Ngly1 | - |
Dictyostelium discoideum |
| Ngly1 | - |
Neurospora crassa |
| Ngly1 | - |
Arabidopsis thaliana |
| Ngly1 | - |
Drosophila melanogaster |
| Ngly1 | - |
Homo sapiens |
| Ngly1 | - |
Schizosaccharomyces pombe |
| peptide:N-glycanase | - |
Oryzias latipes |
| peptide:N-glycanase | - |
Caenorhabditis elegans |
| peptide:N-glycanase | - |
Saccharomyces cerevisiae |
| peptide:N-glycanase | - |
Mus musculus |
| peptide:N-glycanase | - |
Dictyostelium discoideum |
| peptide:N-glycanase | - |
Neurospora crassa |
| peptide:N-glycanase | - |
Arabidopsis thaliana |
| peptide:N-glycanase | - |
Drosophila melanogaster |
| peptide:N-glycanase | - |
Homo sapiens |
| peptide:N-glycanase | - |
Schizosaccharomyces pombe |
| peptide:N-glycanase homolog | UniProt | Neurospora crassa |
| PNG1 | - |
Caenorhabditis elegans |
| PNG1 | - |
Saccharomyces cerevisiae |
| PNG1 | - |
Arabidopsis thaliana |
| PNG1 | - |
Drosophila melanogaster |
| PNG1 | - |
Schizosaccharomyces pombe |
| PNGase | - |
Oryzias latipes |
| PNGase | - |
Caenorhabditis elegans |
| PNGase | - |
Saccharomyces cerevisiae |
| PNGase | - |
Mus musculus |
| PNGase | - |
Dictyostelium discoideum |
| PNGase | - |
Neurospora crassa |
| PNGase | - |
Arabidopsis thaliana |
| PNGase | - |
Drosophila melanogaster |
| PNGase | - |
Homo sapiens |
| PNGase | - |
Schizosaccharomyces pombe |
| TGc domain-containing protein | UniProt | Dictyostelium discoideum |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | in yeast cells, the absence of cytoplasmic PNGase (Png1) results in significant reduction of the levels of free oligosaccharidesfound in the cytosol, suggesting that the majority, if not all, of the free oligosaccharidesin yeast are generated from misfolded glycoproteins in a PNGase-dependent manner. Phenotypes/pathological conditions caused by mutations in gene orthologues of cytoplasmic PNGase are defect in ERAD, but no growth/viability defects | Saccharomyces cerevisiae |
| malfunction | phenotypes/pathological conditions caused by mutations in gene orthologues of cytoplasmic PNGase are abnormal axon branching of VC4/VC5 egg-laying neurons, and egg-laying behaviour defect | Caenorhabditis elegans |
| malfunction | phenotypes/pathological conditions caused by mutations in gene orthologues of cytoplasmic PNGase are global developmental delay, movement disorder, and hypotonia | Drosophila melanogaster |
| malfunction | phenotypes/pathological conditions caused by mutations in gene orthologues of cytoplasmic PNGase are not detected | Arabidopsis thaliana |
| malfunction | phenotypes/pathological conditions caused by mutations in gene orthologues of cytoplasmic PNGase are severe developmental delay. An exome analysis identified a human patient with mutations in the NGLY1 gene and an increasing number of the patients harbouring mutations in NGLY1 alleles have been reported since then. The patients exhibited multiple symptoms that include global developmental delay, multifocal epilepsy, involuntary movement, abnormal liver function and the absence of tears | Homo sapiens |
| malfunction | phenotypes/pathological conditions caused by mutations in gene orthologues of cytoplasmic PNGase are slow growth and development, as well as defect in cell aggregation during multicellular development | Dictyostelium discoideum |
| malfunction | phenotypes/pathological conditions caused by mutations in gene orthologues of cytoplasmic PNGase are temperature-sensitive growth with strong polarity defects | Neurospora crassa |
| physiological function | Fbs1, a glycoprotein-specific ubiquitin ligase, protects misfolded glycoproteins from the action of cytoplasmic PNGase | Mus musculus |
| physiological function | Fbs1, a glycoprotein-specific ubiquitin ligase, protects misfolded glycoproteins from the action of cytoplasmic PNGase | Homo sapiens |
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