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Literature summary for 3.5.1.52 extracted from

  • Altrich-VanLith, M.L.; Ostankovitch, M.; Polefrone, J.M.; Mosse, C.A.; Shabanowitz, J.; Hunt, D.F.; Engelhard, V.H.
    Processing of a class I-restricted epitope from tyrosinase requires peptide N-glycanase and the cooperative action of endoplasmic reticulum aminopeptidase 1 and cytosolic protease (2006), J. Immunol., 177, 5440-5450.
    View publication on PubMed
Search for more literature for 3.5.1.52

Inhibitors

Inhibitors Comment Organism Structure
carbobenzyloxy-Val-Ala-Asp i.e. Z-VAD, in vivo inhibition Homo sapiens
carbobenzyloxy-Val-Ala-Asp-alpha-fluoromethylketone i.e. Z-VAD-fmk, in vivo inhibition Homo sapiens
additional information no inhibition by the caspase inhibitor Q-VD-OPh Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
tyrosinase + H2O Homo sapiens the enzyme is required for processing of a class I-restricted epitope from tyrosinase together with the cooperative action of endoplasmic reticulum aminopeptidase 1 and cytosolic protease, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
tyrosinase + H2O the enzyme is required for processing of a class I-restricted epitope from tyrosinase together with the cooperative action of endoplasmic reticulum aminopeptidase 1 and cytosolic protease, overview Homo sapiens ?
-
 ?
tyrosinase + H2O deglycosylation of tyrosinase at Asn371 and the Tyr369 epitope, reduced activity with tyrosinase peptides that are mutated in the glycosylation consensus sequence to give T373V mutants Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
peptide N-glycanase
-
 Homo sapiens
PNGase
-
 Homo sapiens