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Literature summary for 3.5.1.5 extracted from

  • Abdul Fattah, T.; Saeed, A.; Channar, P.A.; Ashraf, Z.; Abbas, Q.; Hassan, M.; Larik, F.A.
    Synthesis, enzyme inhibitory kinetics, and computational studies of novel 1-(2-(4-isobutylphenyl) propanoyl)-3-arylthioureas as Jack bean urease inhibitors (2018), Chem. Biol. Drug Des., 91, 434-447 .
    View publication on PubMed
Search for more literature for 3.5.1.5

Inhibitors

Inhibitors Comment Organism Structure
2-[4-(2-methylpropyl)phenyl]-N-[(2,4,6-trimethylphenyl)carbamothioyl]propanamide
-
 Canavalia ensiformis
2-[4-(2-methylpropyl)phenyl]-N-[(3-nitrophenyl)carbamothioyl]propanamide
-
 Canavalia ensiformis
2-[4-(2-methylpropyl)phenyl]-N-[(4-sulfamoylphenyl)carbamothioyl]propanamide
-
 Canavalia ensiformis
N-(benzylcarbamothioyl)-2-[4-(2-methylpropyl)phenyl]propanamide
-
 Canavalia ensiformis
N-[(2,3-dichlorophenyl)carbamothioyl]-2-[4-(2-methylpropyl)phenyl]propanamide
-
 Canavalia ensiformis
N-[(2,4-dinitrophenyl)carbamothioyl]-2-[4-(2-methylpropyl)phenyl]propanamide
-
 Canavalia ensiformis
N-[(3,5-dinitrophenyl)carbamothioyl]-2-[4-(2-methylpropyl)phenyl]propanamide
-
 Canavalia ensiformis
N-[(4-bromophenyl)carbamothioyl]-2-[4-(2-methylpropyl)phenyl]propanamide
-
 Canavalia ensiformis
N-[(4-chlorophenyl)carbamothioyl]-2-[4-(2-methylpropyl)phenyl]propanamide
-
 Canavalia ensiformis
N-[(4-methoxyphenyl)carbamothioyl]-2-[4-(2-methylpropyl)phenyl]propanamide
-
 Canavalia ensiformis
Thiourea
-
 Canavalia ensiformis

Organism

Organism UniProt Comment Textmining
Canavalia ensiformis P07374
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
urea + H2O
-
 Canavalia ensiformis CO2 + 2 NH3
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000000012
-
 N-[(2,3-dichlorophenyl)carbamothioyl]-2-[4-(2-methylpropyl)phenyl]propanamide pH 8.2, 37°C, competitive inhibition, irreversible Canavalia ensiformis
0.0000000025
-
 2-[4-(2-methylpropyl)phenyl]-N-[(3-nitrophenyl)carbamothioyl]propanamide pH 8.2, 37°C, mixed-type inhibition Canavalia ensiformis
0.000000003
-
 2-[4-(2-methylpropyl)phenyl]-N-[(2,4,6-trimethylphenyl)carbamothioyl]propanamide pH 8.2, 37°C, mixed-type inhibition Canavalia ensiformis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000209
-
 pH 8.2, 37°C Canavalia ensiformis N-[(4-bromophenyl)carbamothioyl]-2-[4-(2-methylpropyl)phenyl]propanamide
0.00021
-
 pH 8.2, 37°C Canavalia ensiformis N-[(3,5-dinitrophenyl)carbamothioyl]-2-[4-(2-methylpropyl)phenyl]propanamide
0.000211
-
 pH 8.2, 37°C Canavalia ensiformis N-[(2,4-dinitrophenyl)carbamothioyl]-2-[4-(2-methylpropyl)phenyl]propanamide
0.000212
-
 pH 8.2, 37°C Canavalia ensiformis N-(benzylcarbamothioyl)-2-[4-(2-methylpropyl)phenyl]propanamide
0.000215
-
 pH 8.2, 37°C Canavalia ensiformis N-[(4-methoxyphenyl)carbamothioyl]-2-[4-(2-methylpropyl)phenyl]propanamide
0.000218
-
 pH 8.2, 37°C Canavalia ensiformis N-[(4-chlorophenyl)carbamothioyl]-2-[4-(2-methylpropyl)phenyl]propanamide
0.000225
-
 pH 8.2, 37°C, competitive inhibition, irreversible Canavalia ensiformis N-[(2,3-dichlorophenyl)carbamothioyl]-2-[4-(2-methylpropyl)phenyl]propanamide
0.000235
-
 pH 8.2, 37°C Canavalia ensiformis 2-[4-(2-methylpropyl)phenyl]-N-[(4-sulfamoylphenyl)carbamothioyl]propanamide
0.000235
-
 pH 8.2, 37°C, mixed-type inhibition Canavalia ensiformis 2-[4-(2-methylpropyl)phenyl]-N-[(3-nitrophenyl)carbamothioyl]propanamide
18.5
-
 pH 8.2, 37°C Canavalia ensiformis Thiourea