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Literature summary for 3.5.1.5 extracted from

  • Qu, D.; Niu, F.; Zhao, X.; Yan, K.X.; Ye, Y.T.; Wang, J.; Zhang, M.; You, Z.
    Synthesis, crystal structures, and urease inhibition of an acetohydroxamate-coordinated oxovanadium(V) complex derived from N-(3-bromo-2-hydroxybenzylidene)-4-methoxybenzohydrazide (2015), Bioorg. Med. Chem., 23, 1944-1949 .
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
oxovanadium complex [VOL(AHA)] reaction of N'-(3-bromo-2-hydroxybenzylidene)-4-methoxybenzohydrazide and acetohydroxamic acid with VO(acac)2 in methanol gives the complex [VOL(AHA)]. The benzohydrazone ligand, in its dianionic form, coordinates to V atom through the phenolate oxygen, imino nitrogen and enolate oxygen. The acetohydroxamic acid coordinates to V atom through the carbonyl oxygen and deprotonated hydroxyl oxygen. The V atom is in octahedral coordination. The percent inhibition at concentration of 0.1 mM/l on Helicobacter pylori urease is 78% for the oxovanadium complex Helicobacter pylori

Organism

Organism UniProt Comment Textmining
Helicobacter pylori
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-
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Helicobacter pylori ATCC 43504
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-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0365
-
 37°C, pH 7.4 Helicobacter pylori oxovanadium complex [VOL(AHA)]