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Literature summary for 3.5.1.5 extracted from

  • Aslam, M.A.; Mahmood, S.U.; Shahid, M.; Saeed, A.; Iqbal, J.
    Synthesis, biological assay in vitro and molecular docking studies of new Schiff base derivatives as potential urease inhibitors (2011), Eur. J. Med. Chem., 46, 5473-5479.
    View publication on PubMed
Search for more literature for 3.5.1.5

Inhibitors

Inhibitors Comment Organism Structure
(E)-1-((E)-3-phenylallylidene)thiosemicarbazide
-
 Canavalia ensiformis
(E)-1-(2-chlorobenzylidene)thiosemicarbazide
-
 Canavalia ensiformis
(E)-1-(3,4,5-trimethoxybenzylidene)thiosemicarbazide
-
 Canavalia ensiformis
(E)-1-(3-bromobenzylidene)thiosemicarbazide
-
 Canavalia ensiformis
(E)-1-(3-chlorobenzylidene)thiosemicarbazide
-
 Canavalia ensiformis
(E)-1-(3-methoxybenzylidene)thiosemicarbazide
-
 Canavalia ensiformis
(E)-1-(3-nitrobenzylidene)thiosemicarbazide competitive mechanism of inhibition Canavalia ensiformis
(E)-1-(4-(N,N-dimethylamino)benzylidene)thiosemicarbazide
-
 Canavalia ensiformis
(E)-1-(4-bromobenzylidene)thiosemicarbazide
-
 Canavalia ensiformis
(E)-1-(4-chlorobenzylidene)thiosemicarbazide
-
 Canavalia ensiformis
(E)-1-(4-methoxybenzylidene)thiosemicarbazide
-
 Canavalia ensiformis
(E)-1-(4-nitrobenzylidene)thiosemicarbazide
-
 Canavalia ensiformis
(E)-2-((E)-but-2-enylidene)hydrazinecarbothioamide
-
 Canavalia ensiformis
(E)-2-(2,3-dihydroxybenzylidene)hydrazinecarbothioamide
-
 Canavalia ensiformis
(E)-2-(2-(benzyloxy)benzylidene)hydrazinecarbothioamide
-
 Canavalia ensiformis
(E)-2-(3-(benzyloxy)-4-methoxybenzylidene)hydrazinecarbothioamide
-
 Canavalia ensiformis
(E)-2-(4-hydroxy-3,5-dimethoxybenzylidene)hydrazinecarbothioamide
-
 Canavalia ensiformis
(E)-2-(4-hydroxybenzylidene)hydrazinecarbothioamide
-
 Canavalia ensiformis
Thiourea
-
 Canavalia ensiformis

Organism

Organism UniProt Comment Textmining
Canavalia ensiformis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
urea + H2O
-
 Canavalia ensiformis CO2 + 2 NH3
-
 ?

Synonyms

Synonyms Comment Organism
urease
-
 Canavalia ensiformis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00009
-
 (E)-1-(3-nitrobenzylidene)thiosemicarbazide pH 8.2, 37°C Canavalia ensiformis
0.000122
-
 (E)-1-(4-(N,N-dimethylamino)benzylidene)thiosemicarbazide pH 8.2, 37°C Canavalia ensiformis
0.000127
-
 (E)-1-(3-methoxybenzylidene)thiosemicarbazide pH 8.2, 37°C Canavalia ensiformis
0.000127
-
 (E)-2-(2,3-dihydroxybenzylidene)hydrazinecarbothioamide pH 8.2, 37°C Canavalia ensiformis
0.000134
-
 (E)-2-(4-hydroxy-3,5-dimethoxybenzylidene)hydrazinecarbothioamide pH 8.2, 37°C Canavalia ensiformis
0.000152
-
 (E)-2-(2-(benzyloxy)benzylidene)hydrazinecarbothioamide pH 8.2, 37°C Canavalia ensiformis
0.00017
-
 (E)-1-(2-chlorobenzylidene)thiosemicarbazide pH 8.2, 37°C Canavalia ensiformis
0.000191
-
 (E)-2-(3-(benzyloxy)-4-methoxybenzylidene)hydrazinecarbothioamide pH 8.2, 37°C Canavalia ensiformis
0.000391
-
 (E)-2-(4-hydroxybenzylidene)hydrazinecarbothioamide pH 8.2, 37°C Canavalia ensiformis
0.000398
-
 (E)-1-(4-chlorobenzylidene)thiosemicarbazide pH 8.2, 37°C Canavalia ensiformis
0.000407
-
 (E)-1-((E)-3-phenylallylidene)thiosemicarbazide pH 8.2, 37°C Canavalia ensiformis
0.00043
-
 (E)-2-((E)-but-2-enylidene)hydrazinecarbothioamide pH 8.2, 37°C Canavalia ensiformis
0.000497
-
 (E)-1-(4-nitrobenzylidene)thiosemicarbazide pH 8.2, 37°C Canavalia ensiformis
0.000625
-
 (E)-1-(3-chlorobenzylidene)thiosemicarbazide pH 8.2, 37°C Canavalia ensiformis
0.00067
-
 (E)-1-(3-bromobenzylidene)thiosemicarbazide pH 8.2, 37°C Canavalia ensiformis
0.00077
-
 (E)-1-(4-bromobenzylidene)thiosemicarbazide pH 8.2, 37°C Canavalia ensiformis
0.000807
-
 (E)-1-(4-methoxybenzylidene)thiosemicarbazide pH 8.2, 37°C Canavalia ensiformis
0.00091
-
 (E)-1-(3,4,5-trimethoxybenzylidene)thiosemicarbazide pH 8.2, 37°C Canavalia ensiformis
0.0196
-
 Thiourea pH 8.2, 37°C Canavalia ensiformis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000102
-
 pH 8.2, 37°C Canavalia ensiformis (E)-1-(3-nitrobenzylidene)thiosemicarbazide
0.000127
-
 pH 8.2, 37°C Canavalia ensiformis (E)-1-(4-(N,N-dimethylamino)benzylidene)thiosemicarbazide
0.000177
-
 pH 8.2, 37°C Canavalia ensiformis (E)-1-(3-methoxybenzylidene)thiosemicarbazide
0.000215
-
 pH 8.2, 37°C Canavalia ensiformis (E)-1-(2-chlorobenzylidene)thiosemicarbazide
0.00022
-
 pH 8.2, 37°C Canavalia ensiformis (E)-2-(2,3-dihydroxybenzylidene)hydrazinecarbothioamide
0.000233
-
 pH 8.2, 37°C Canavalia ensiformis (E)-2-(4-hydroxy-3,5-dimethoxybenzylidene)hydrazinecarbothioamide
0.000263
-
 pH 8.2, 37°C Canavalia ensiformis (E)-2-(2-(benzyloxy)benzylidene)hydrazinecarbothioamide
0.00033
-
 pH 8.2, 37°C Canavalia ensiformis (E)-2-(3-(benzyloxy)-4-methoxybenzylidene)hydrazinecarbothioamide
0.00041
-
 pH 8.2, 37°C Canavalia ensiformis (E)-1-(4-chlorobenzylidene)thiosemicarbazide
0.000457
-
 pH 8.2, 37°C Canavalia ensiformis (E)-1-((E)-3-phenylallylidene)thiosemicarbazide
0.000547
-
 pH 8.2, 37°C Canavalia ensiformis (E)-1-(4-nitrobenzylidene)thiosemicarbazide
0.00067
-
 pH 8.2, 37°C Canavalia ensiformis (E)-1-(3-chlorobenzylidene)thiosemicarbazide
0.000682
-
 pH 8.2, 37°C Canavalia ensiformis (E)-2-(4-hydroxybenzylidene)hydrazinecarbothioamide
0.000707
-
 pH 8.2, 37°C Canavalia ensiformis (E)-1-(4-bromobenzylidene)thiosemicarbazide
0.000746
-
 pH 8.2, 37°C Canavalia ensiformis (E)-2-((E)-but-2-enylidene)hydrazinecarbothioamide
0.000767
-
 pH 8.2, 37°C Canavalia ensiformis (E)-1-(3-bromobenzylidene)thiosemicarbazide
0.000887
-
 pH 8.2, 37°C Canavalia ensiformis (E)-1-(4-methoxybenzylidene)thiosemicarbazide
0.000989
-
 pH 8.2, 37°C Canavalia ensiformis (E)-1-(3,4,5-trimethoxybenzylidene)thiosemicarbazide
0.021
-
 pH 8.2, 37°C Canavalia ensiformis Thiourea