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Literature summary for 3.5.1.48 extracted from

  • Suzuke, O.; Kumazawa, T.; Seno, H.; Matsumoto, T.
    Acetylspermidine deacetylase activities in human organs (1987), Med. Sci. Res., 15, 675-676.
No PubMed abstract available
Search for more literature for 3.5.1.48

Inhibitors

Inhibitors Comment Organism Structure
2-mercaptoethanol slight inhibition at 1 mM Homo sapiens
8-hydroxyquinoline slight inhibition at 1 mM Homo sapiens
Acriflavin strong inhibition at 1 mM Homo sapiens
Cu2+ nearly complete inhibition at 1 mM Homo sapiens
dithiothreitol remarkable inhibition at 1 mM Homo sapiens
Fe2+ strong inhibition at 1 mM Homo sapiens
iodoacetamide slight inhibition at 1 mM Homo sapiens
NaN3 slight inhibition at 1 mM Homo sapiens
p-chloromercuribenzoic acid complete inhibition at 1 mM Homo sapiens
Pargyline slight inhibition at 1 mM Homo sapiens
Quinacrine strong inhibition at 1 mM Homo sapiens
Semicarbazide slight inhibition at 1 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.211
-
 N8-Acetylspermidine
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain lowest activity level Homo sapiens
-
heart
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
liver highest activity level Homo sapiens
-
lung
-
 Homo sapiens
-
pancreas
-
 Homo sapiens
-
small intestine
-
 Homo sapiens
-
spleen
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
diacetylspermidine + H2O 81.9% activity of that of N8-acetylspermidine Homo sapiens acetate + spermidine
-
 ?
N1-acetylspermidine + H2O low activity Homo sapiens acetate + spermidine
-
 ?
N8-acetylspermidine + H2O highest activity Homo sapiens acetate + spermidine
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8 8.5
-
 Homo sapiens