Cloned (Comment) | Organism |
---|---|
recombinant expression of NMN deamidase fused to EGFP in transgenic mice and zebrafish larvae | Escherichia coli |
Protein Variants | Comment | Organism |
---|---|---|
additional information | NMN deamidase blocks Wallerian degeneration in transgenic zebrafish larvae. NMN deamidase also rescues axonal outgrowth and perinatal lethality in a dose-dependent manner in mice lacking NMNAT2. Recombinant NMN deamidase delays Wallerian degeneration and rescues axonal defects caused by NMNAT2 deficiency in vivo. NMN deamidase protection is neuron specific and effective against various toxic insults. NMN deamidase expression confers morphological and functional preservation of transected axons | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
nicotinamide mononucleotide + H2O | Escherichia coli | - |
nicotinate mononucleotide + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | NMN deamidase lacks intrinsic NAD synthesis activity | Escherichia coli | ? | - |
? | |
nicotinamide mononucleotide + H2O | - |
Escherichia coli | nicotinate mononucleotide + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NMN deamidase | - |
Escherichia coli |
General Information | Comment | Organism |
---|---|---|
physiological function | recombinant NMN deamidase delays Wallerian degeneration and rescues axonal defects caused by NMNAT2 deficiency in vivo. NMN-consuming activity with axonal NAD-synthesizing enzyme NMNAT2, but not NAD-synthesizing activity, and it delays axon degeneration in primary neuronal cultures. Transgenic NMN deamidase protection is neuron specific and effective against various toxic insults. NMN deamidase prevents NMN accumulation in injured sciatic nerves | Escherichia coli |