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Literature summary for 3.5.1.42 extracted from
- Nicotinamide nucleoside amidase activity, a novel deamidating reaction in NAD metabolism, in Aspergillus fungi (1983), J. Ferment. Technol., 61, 61-66.
No PubMed abstract available
General Stability
| General Stability | Organism |
|---|---|
| unstable during purification procedure | Aspergillus niger |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Hg2+ | 52% inhibition at 1 mM | Aspergillus niger |  |
| p-hydroxymercuribenzoate | 26% inhibition at 1 mM | Aspergillus niger | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 3.6 | - |
beta-nicotinamide D-ribonucleoside | - |
Aspergillus niger | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 33000 | - |
gel filtration | Aspergillus usamii |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| nicotinamide ribonucleoside + H2O | Aspergillus niger | highly specific | nicotinic acid ribonucleoside + NH3 | - |
? | |
| nicotinamide ribonucleoside + H2O | Rhizopus arrhizus | highly specific | nicotinic acid ribonucleoside + NH3 | - |
? | |
| nicotinamide ribonucleoside + H2O | Aspergillus flavus | highly specific | nicotinic acid ribonucleoside + NH3 | - |
? | |
| nicotinamide ribonucleoside + H2O | Aspergillus oryzae | highly specific | nicotinic acid ribonucleoside + NH3 | - |
? | |
| nicotinamide ribonucleoside + H2O | Trichoderma deliquescens | highly specific | nicotinic acid ribonucleoside + NH3 | - |
? | |
| nicotinamide ribonucleoside + H2O | Fusarium oxysporum | highly specific | nicotinic acid ribonucleoside + NH3 | - |
? | |
| nicotinamide ribonucleoside + H2O | Aspergillus awamori | highly specific | nicotinic acid ribonucleoside + NH3 | - |
? | |
| nicotinamide ribonucleoside + H2O | Aspergillus usamii | highly specific | nicotinic acid ribonucleoside + NH3 | - |
? | |
| nicotinamide ribonucleoside + H2O | Athelia rolfsii | highly specific | nicotinic acid ribonucleoside + NH3 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aspergillus awamori | - |
- |
- |
| Aspergillus flavus | - |
- |
- |
| Aspergillus niger | - |
- |
- |
| Aspergillus oryzae | - |
- |
- |
| Aspergillus usamii | - |
- |
- |
| Athelia rolfsii | - |
- |
- |
| Fusarium oxysporum | - |
- |
- |
| Rhizopus arrhizus | - |
- |
- |
| Trichoderma deliquescens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Aspergillus niger |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cell culture | - |
Aspergillus niger | - |
| cell culture | - |
Rhizopus arrhizus | - |
| cell culture | - |
Aspergillus flavus | - |
| cell culture | - |
Aspergillus oryzae | - |
| cell culture | - |
Trichoderma deliquescens | - |
| cell culture | - |
Fusarium oxysporum | - |
| cell culture | - |
Aspergillus awamori | - |
| cell culture | - |
Aspergillus usamii | - |
| cell culture | - |
Athelia rolfsii | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.38 | - |
- |
Aspergillus niger |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-nicotinamide D-ribonucleoside + H2O | - |
Aspergillus niger | beta-nicotinate D-ribonucleoside + NH3 | - |
? | |
| nicotinamide ribonucleoside + H2O | highly specific | Aspergillus niger | nicotinic acid ribonucleoside + NH3 | - |
? | |
| nicotinamide ribonucleoside + H2O | highly specific | Rhizopus arrhizus | nicotinic acid ribonucleoside + NH3 | - |
? | |
| nicotinamide ribonucleoside + H2O | highly specific | Aspergillus flavus | nicotinic acid ribonucleoside + NH3 | - |
? | |
| nicotinamide ribonucleoside + H2O | highly specific | Aspergillus oryzae | nicotinic acid ribonucleoside + NH3 | - |
? | |
| nicotinamide ribonucleoside + H2O | highly specific | Trichoderma deliquescens | nicotinic acid ribonucleoside + NH3 | - |
? | |
| nicotinamide ribonucleoside + H2O | highly specific | Fusarium oxysporum | nicotinic acid ribonucleoside + NH3 | - |
? | |
| nicotinamide ribonucleoside + H2O | highly specific | Aspergillus awamori | nicotinic acid ribonucleoside + NH3 | - |
? | |
| nicotinamide ribonucleoside + H2O | highly specific | Aspergillus usamii | nicotinic acid ribonucleoside + NH3 | - |
? | |
| nicotinamide ribonucleoside + H2O | highly specific | Athelia rolfsii | nicotinic acid ribonucleoside + NH3 | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 45 | - |
- |
Aspergillus niger |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | - |
- |
Aspergillus niger |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 5.5 | maximal activity within | Aspergillus niger |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 6 | stable within for 30 min | Aspergillus niger |
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Release 2023.1 (January 2023)
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