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Literature summary for 3.5.1.4 extracted from

  • Wei, B.Q.; Mikkelsen, T.S.; McKinney, M.K.; Lander, E.S.; Cravatt, B.F.
    A second fatty acid amide hydrolase with variable distribution among placental mammals (2006), J. Biol. Chem., 281, 36569-36578.
    View publication on PubMed
Search for more literature for 3.5.1.4

Inhibitors

Inhibitors Comment Organism Structure
3'-(aminocarbonyl)biphenyl-3-yl cyclohexylcarbamate
-
 Homo sapiens
3'-carbamoylbiphenyl-3-yl undec-10-yn-1-ylcarbamate
-
 Homo sapiens
4-(benzyloxy)phenyl butylcarbamate
-
 Homo sapiens
7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane FAAH-1 shows predominantly cytoplasmic orientation Homo sapiens 16020
-
membrane FAAH-2 is luminally orientated in the membrane Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens FAAH-1 plays a primary role in regulating endocannabinoid signaling ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O00519 from COS-7 cells transfected with human FAAH-1
-
Homo sapiens Q6GMR7 from COS-7 cells transfected with human FAAH-1
-

Source Tissue

Source Tissue Comment Organism Textmining
brain FAAH-1 is highly expressed Homo sapiens
-
heart FAAH-2 Homo sapiens
-
kidney FAAH-1 Homo sapiens
-
kidney FAAH-2 Homo sapiens
-
liver FAAH-1 Homo sapiens
-
liver FAAH-2 Homo sapiens
-
lung FAAH-1 Homo sapiens
-
lung FAAH-2 Homo sapiens
-
additional information no FAAH-1 activity is detected in heart Homo sapiens
-
prostate FAAH-1 Homo sapiens
-
prostate FAAH-2 Homo sapiens
-
small intestine FAAH-1 is highly expressed Homo sapiens
-
testis FAAH-1 is highly expressed Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
anandamide + H2O FAAH-1 Homo sapiens arachidonic acid + ethanolamine
-
 ?
anandamide + H2O FAAH-2 Homo sapiens arachidonic acid + ethanolamine
-
 ?
additional information FAAH-1 plays a primary role in regulating endocannabinoid signaling Homo sapiens ?
-
 ?
additional information no FAAH-2 activity is detected with N-oleoyl taurine Homo sapiens ?
-
 ?
N-oleoyl ethanolamine + H2O FAAH-1 Homo sapiens oleic acid + ethanolamine
-
 ?
N-oleoyl ethanolamine + H2O FAAH-2 Homo sapiens oleic acid + ethanolamine
-
 ?
N-oleoyl taurine + H2O FAAH-1 Homo sapiens oleic acid + taurine
-
 ?
N-palmitolyl ethanolamine + H2O FAAH-1 Homo sapiens palmitic acid + ethanolamine
-
 ?
N-palmitolyl ethanolamine + H2O FAAH-2 Homo sapiens palmitic acid + ethanolamine
-
 ?
oleamide + H2O FAAH-1 Homo sapiens oleic acid + NH3
-
 ?
oleamide + H2O FAAH-2 Homo sapiens oleic acid + NH3
-
 ?

Synonyms

Synonyms Comment Organism
FAAH-1
-
 Homo sapiens
FAAH-2
-
 Homo sapiens
fatty acid amide hydrolase
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00000038
-
-
 Homo sapiens 3'-carbamoylbiphenyl-3-yl undec-10-yn-1-ylcarbamate
0.000001
-
-
 Homo sapiens 3'-carbamoylbiphenyl-3-yl undec-10-yn-1-ylcarbamate
0.0000134
-
-
 Homo sapiens 7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
0.000206
-
-
 Homo sapiens 7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one
0.000283
-
-
 Homo sapiens 4-(benzyloxy)phenyl butylcarbamate
0.00136
-
-
 Homo sapiens 4-(benzyloxy)phenyl butylcarbamate