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Literature summary for 3.5.1.4 extracted from

  • Jin, S.J.; Zheng, R.C.; Zheng, Y.G.; Shen, Y.C.
    R-enantioselective hydrolysis of 2,2-dimethylcyclopropanecarboxamide by amidase from a newly isolated strain Brevibacterium epidermidis ZJB-07021 (2008), J. Appl. Microbiol., 105, 1150-1157.
    View publication on PubMed
Search for more literature for 3.5.1.4

Organism

Organism UniProt Comment Textmining
Brevibacterium epidermidis
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Brevibacterium epidermidis ZJB-07021
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,2-dimethylcyclopropanecarboxamide + H2O 70 min of bioconversion at 35°C, kinetic resolution of (R,S)-2,2-dimethylcyclopropanecarboxamide by the amidase affords (S)-2,2-dimethylcyclopropanecarboxamide in 41.1% yield (>99% ee) and (R)-2,2-dimethylcyclopropanecarboxylic acid in 49.9% yield (69.7% ee). The enantioselectivity is temperature dependent and is enhanced from 12.6 at 45°C to 65.9 at 14°C Brevibacterium epidermidis (R)-2,2-dimethylcyclopropanecarboxylic acid + NH3
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2,2-dimethylcyclopropanecarboxamide + H2O 70 min of bioconversion at 35°C, kinetic resolution of (R,S)-2,2-dimethylcyclopropanecarboxamide by the amidase affords (S)-2,2-dimethylcyclopropanecarboxamide in 41.1% yield (>99% ee) and (R)-2,2-dimethylcyclopropanecarboxylic acid in 49.9% yield (69.7% ee). The enantioselectivity is temperature dependent and is enhanced from 12.6 at 45°C to 65.9 at 14°C Brevibacterium epidermidis ZJB-07021 (R)-2,2-dimethylcyclopropanecarboxylic acid + NH3
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 ?

Synonyms

Synonyms Comment Organism
R-stereospecific amidase
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 Brevibacterium epidermidis