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Literature summary for 3.5.1.4 extracted from
- The N-acylethanolamine-hydrolyzing acid amidase (NAAA) (2007), Chem. Biodivers., 4, 1914-1925.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| dithiothreitol | activates | Homo sapiens |  |
| dithiothreitol | activates | Rattus norvegicus | |
| dithiothreitol | activates | Mus musculus | |
| additional information | no activation by dithiothreitol | Mus musculus | |
| additional information | no activation by dithiothreitol | Rattus norvegicus | |
| additional information | no activation by dithiothreitol | Homo sapiens | |
| additional information | no activation by dithiothreitol | Sus scrofa |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| DNA containing thymine glycol | - |
Homo sapiens | |
| DNA containing thymine glycol | - |
Mus musculus | |
| DNA containing thymine glycol | - |
Rattus norvegicus | |
| DNA containing thymine glycol | - |
Sus scrofa | |
| N-(cyclohexylcarbonyl)pentadecylamine | - |
Homo sapiens | |
| N-(cyclohexylcarbonyl)pentadecylamine | - |
Mus musculus | |
| N-(cyclohexylcarbonyl)pentadecylamine | - |
Rattus norvegicus | |
| PCMB | - |
Homo sapiens | |
| PCMB | - |
Mus musculus | |
| PCMB | - |
Rattus norvegicus | |
| PMSF | - |
Homo sapiens | |
| PMSF | - |
Mus musculus | |
| PMSF | - |
Rattus norvegicus | |
| PMSF | - |
Sus scrofa | |
| URB597 | - |
Homo sapiens | |
| URB597 | - |
Mus musculus | |
| URB597 | - |
Rattus norvegicus | |
| URB597 | - |
Sus scrofa | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| lysosome | - |
Homo sapiens | 5764 | - |
| lysosome | - |
Rattus norvegicus | 5764 | - |
| lysosome | - |
Mus musculus | 5764 | - |
| membrane | - |
Mus musculus | 16020 | - |
| membrane | - |
Rattus norvegicus | 16020 | - |
| membrane | - |
Homo sapiens | 16020 | - |
| membrane | - |
Sus scrofa | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O00519 | - |
- |
| Homo sapiens | Q02083 | - |
- |
| Mus musculus | O08914 | - |
- |
| Mus musculus | Q9D7V9 | - |
- |
| Rattus norvegicus | P97612 | - |
- |
| Rattus norvegicus | Q5KTC7 | - |
- |
| Sus scrofa | Q9TUI8 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| brain | - |
Rattus norvegicus | - |
| brain | - |
Homo sapiens | - |
| brain | - |
Sus scrofa | - |
| liver | - |
Mus musculus | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Sus scrofa | - |
| lung | - |
Homo sapiens | - |
| lung | - |
Rattus norvegicus | - |
| lung | - |
Mus musculus | - |
| small intestine | - |
Homo sapiens | - |
| small intestine | - |
Rattus norvegicus | - |
| small intestine | - |
Mus musculus | - |
| small intestine | - |
Sus scrofa | - |
| spleen | - |
Homo sapiens | - |
| spleen | - |
Rattus norvegicus | - |
| spleen | - |
Mus musculus | - |
| testis | - |
Mus musculus | - |
| testis | - |
Rattus norvegicus | - |
| testis | - |
Homo sapiens | - |
| testis | - |
Sus scrofa | - |
| thymus | - |
Homo sapiens | - |
| thymus | - |
Rattus norvegicus | - |
| thymus | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-arachidonoylglycerol + H2O | - |
Homo sapiens | arachidonic acid + glycerol | - |
? | |
| 2-arachidonoylglycerol + H2O | - |
Sus scrofa | arachidonic acid + glycerol | - |
? | |
| 2-arachidonoylglycerol + H2O | - |
Mus musculus | ? | - |
? | |
| 2-arachidonoylglycerol + H2O | - |
Rattus norvegicus | ? | - |
? | |
| anandamide + H2O | substrates in order of decreasing activity: anandamide, N-oleoylethanolamine, N-palmitoylethanolamine | Mus musculus | arachidonic acid + ethanolamine | - |
? | |
| anandamide + H2O | substrates in order of decreasing activity: anandamide, N-oleoylethanolamine, N-palmitoylethanolamine | Rattus norvegicus | arachidonic acid + ethanolamine | - |
? | |
| anandamide + H2O | substrates in order of decreasing activity: anandamide, N-oleoylethanolamine, N-palmitoylethanolamine | Homo sapiens | arachidonic acid + ethanolamine | - |
? | |
| anandamide + H2O | substrates in order of decreasing activity: anandamide, N-oleoylethanolamine, N-palmitoylethanolamine | Sus scrofa | arachidonic acid + ethanolamine | - |
? | |
| anandamide + H2O | substrates in order of decreasing activity: N-palmitoylethanolamine, N-oleoylethanolamine, anandamide | Homo sapiens | arachidonic acid + ethanolamine | - |
? | |
| anandamide + H2O | substrates in order of decreasing activity: N-palmitoylethanolamine, N-oleoylethanolamine, anandamide | Rattus norvegicus | arachidonic acid + ethanolamine | - |
? | |
| anandamide + H2O | substrates in order of decreasing activity: N-palmitoylethanolamine, N-oleoylethanolamine, anandamide | Mus musculus | arachidonic acid + ethanolamine | - |
? | |
| additional information | hardly hydrolyzes 2-arachidonoylglycerol | Homo sapiens | ? | - |
? | |
| additional information | hardly hydrolyzes 2-arachidonoylglycerol | Rattus norvegicus | ? | - |
? | |
| additional information | hardly hydrolyzes 2-arachidonoylglycerol | Mus musculus | ? | - |
? | |
| N-oleoylethanolamine + H2O | substrates in order of decreasing activity: anandamide, N-oleoylethanolamine, N-palmitoylethanolamine | Mus musculus | oleic acid + ethanolamine | - |
? | |
| N-oleoylethanolamine + H2O | substrates in order of decreasing activity: anandamide, N-oleoylethanolamine, N-palmitoylethanolamine | Rattus norvegicus | oleic acid + ethanolamine | - |
? | |
| N-oleoylethanolamine + H2O | substrates in order of decreasing activity: anandamide, N-oleoylethanolamine, N-palmitoylethanolamine | Homo sapiens | oleic acid + ethanolamine | - |
? | |
| N-oleoylethanolamine + H2O | substrates in order of decreasing activity: anandamide, N-oleoylethanolamine, N-palmitoylethanolamine | Sus scrofa | oleic acid + ethanolamine | - |
? | |
| N-oleoylethanolamine + H2O | substrates in order of decreasing activity: N-palmitoylethanolamine, N-oleoylethanolamine, anandamide | Homo sapiens | oleic acid + ethanolamine | - |
? | |
| N-oleoylethanolamine + H2O | substrates in order of decreasing activity: N-palmitoylethanolamine, N-oleoylethanolamine, anandamide | Rattus norvegicus | oleic acid + ethanolamine | - |
? | |
| N-oleoylethanolamine + H2O | substrates in order of decreasing activity: N-palmitoylethanolamine, N-oleoylethanolamine, anandamide | Mus musculus | oleic acid + ethanolamine | - |
? | |
| N-palmitoylethanolamine + H2O | substrates in order of decreasing activity: anandamide, N-oleoylethanolamine, N-palmitoylethanolamine | Mus musculus | palmitic acid + ethanolamine | - |
? | |
| N-palmitoylethanolamine + H2O | substrates in order of decreasing activity: anandamide, N-oleoylethanolamine, N-palmitoylethanolamine | Rattus norvegicus | palmitic acid + ethanolamine | - |
? | |
| N-palmitoylethanolamine + H2O | substrates in order of decreasing activity: anandamide, N-oleoylethanolamine, N-palmitoylethanolamine | Homo sapiens | palmitic acid + ethanolamine | - |
? | |
| N-palmitoylethanolamine + H2O | substrates in order of decreasing activity: anandamide, N-oleoylethanolamine, N-palmitoylethanolamine | Sus scrofa | palmitic acid + ethanolamine | - |
? | |
| N-palmitoylethanolamine + H2O | substrates in order of decreasing activity: N-palmitoylethanolamine, N-oleoylethanolamine, anandamide | Homo sapiens | palmitic acid + ethanolamine | - |
? | |
| N-palmitoylethanolamine + H2O | substrates in order of decreasing activity: N-palmitoylethanolamine, N-oleoylethanolamine, anandamide | Rattus norvegicus | palmitic acid + ethanolamine | - |
? | |
| N-palmitoylethanolamine + H2O | substrates in order of decreasing activity: N-palmitoylethanolamine, N-oleoylethanolamine, anandamide | Mus musculus | palmitic acid + ethanolamine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FAAH-1 | - |
Mus musculus |
| FAAH-1 | - |
Rattus norvegicus |
| FAAH-1 | - |
Homo sapiens |
| FAAH-1 | - |
Sus scrofa |
| fatty acid amide hydrolase 1 | - |
Mus musculus |
| fatty acid amide hydrolase 1 | - |
Rattus norvegicus |
| fatty acid amide hydrolase 1 | - |
Homo sapiens |
| fatty acid amide hydrolase 1 | - |
Sus scrofa |
| N-acylethanolaminehydrolyzing acid amidase | - |
Homo sapiens |
| N-acylethanolaminehydrolyzing acid amidase | - |
Rattus norvegicus |
| N-acylethanolaminehydrolyzing acid amidase | - |
Mus musculus |
| NAAA | - |
Homo sapiens |
| NAAA | - |
Rattus norvegicus |
| NAAA | - |
Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 4.5 | 5 | - |
Homo sapiens |
| 4.5 | 5 | - |
Rattus norvegicus |
| 4.5 | 5 | - |
Mus musculus |
| 8.5 | 10 | - |
Mus musculus |
| 8.5 | 10 | - |
Rattus norvegicus |
| 8.5 | 10 | - |
Homo sapiens |
| 8.5 | 10 | - |
Sus scrofa |
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