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Literature summary for 3.5.1.3 extracted from
- The glutamine transaminase-omega-amidase system in rat and human brain (1977), J. Neurochem., 28, 771-778.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
| cytoplasm | 75% of omega-amidase is present in cytoplasm, only 25% of omega-amidase activity is associated with mitochondrial fraction | Rattus norvegicus | 5737 | - |
| cytoplasm | most of omega-amidase activity is present in cytoplasm | Rattus norvegicus | 5737 | - |
| microsome | little activity | Rattus norvegicus | - |
- |
| mitochondrion | 75% of omega-amidase is present in cytoplasm, only 25% of omega-amidase activity is associated with mitochondrial fraction | Rattus norvegicus | 5739 | - |
| additional information | distribution | Homo sapiens | - |
- |
| additional information | distribution | Rattus norvegicus | - |
- |
| additional information | subcellular localization | Homo sapiens | - |
- |
| additional information | subcellular localization | Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-oxoglutaramate + H2O | Homo sapiens | alpha-ketoglutaramate | 2-oxoglutarate + NH3 | - |
? |  |
| 2-oxoglutaramate + H2O | Rattus norvegicus | alpha-ketoglutaramate | 2-oxoglutarate + NH3 | - |
? | |
| additional information | Homo sapiens | enzyme of glutamine-transaminase-omega-amidase pathway, role in degradation of glutamine | ? | - |
? | |
| additional information | Rattus norvegicus | enzyme of glutamine-transaminase-omega-amidase pathway, role in degradation of glutamine | ? | - |
? | |
| additional information | Homo sapiens | pathway for brain glutamine metabolism involves glutamine transaminase-omega-maidase pathway, L-glutamine: 2-oxo-acid amino-transferase, EC 2.6.1.15 and omega-amidodicarboxylate amidohydrolase, EC 3.5.1.3 | ? | - |
? | |
| additional information | Rattus norvegicus | pathway for brain glutamine metabolism involves glutamine transaminase-omega-maidase pathway, L-glutamine: 2-oxo-acid amino-transferase, EC 2.6.1.15 and omega-amidodicarboxylate amidohydrolase, EC 3.5.1.3 | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
human | - |
| Rattus norvegicus | - |
male Sprague-Dawley rat | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | regional activities in brain | Homo sapiens | - |
| brain | regional activities in brain | Rattus norvegicus | - |
| brain | widespread in brain | Homo sapiens | - |
| brain | widespread in brain | Rattus norvegicus | - |
| caudate nucleus | - |
Homo sapiens | - |
| caudate putamen | - |
Homo sapiens | - |
| cerebellum | - |
Homo sapiens | - |
| choroid plexus | - |
Rattus norvegicus | - |
| frontal lobe | - |
Homo sapiens | - |
| parietal cortex | - |
Homo sapiens | - |
| thalamus | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Homo sapiens |
| additional information | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-oxoglutaramate + H2O | alpha-ketoglutaramate | Homo sapiens | 2-oxoglutarate + NH3 | - |
? | |
| 2-oxoglutaramate + H2O | alpha-ketoglutaramate | Rattus norvegicus | 2-oxoglutarate + NH3 | - |
? | |
| additional information | enzyme of glutamine-transaminase-omega-amidase pathway, role in degradation of glutamine | Homo sapiens | ? | - |
? | |
| additional information | enzyme of glutamine-transaminase-omega-amidase pathway, role in degradation of glutamine | Rattus norvegicus | ? | - |
? | |
| additional information | pathway for brain glutamine metabolism involves glutamine transaminase-omega-maidase pathway, L-glutamine: 2-oxo-acid amino-transferase, EC 2.6.1.15 and omega-amidodicarboxylate amidohydrolase, EC 3.5.1.3 | Homo sapiens | ? | - |
? | |
| additional information | pathway for brain glutamine metabolism involves glutamine transaminase-omega-maidase pathway, L-glutamine: 2-oxo-acid amino-transferase, EC 2.6.1.15 and omega-amidodicarboxylate amidohydrolase, EC 3.5.1.3 | Rattus norvegicus | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
assay at | Homo sapiens |
| 8.5 | - |
assay at | Rattus norvegicus |
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Release 2023.1 (January 2023)
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