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Literature summary for 3.5.1.3 extracted from

  • Cooper, A.J.L.; Abraham, D.G.; Gelbard, A.S.; Lai, J.C.K.; Petito, C.K.
    High activities of glutamine transaminase K (dichlorovinylcysteine beta-lyase) and omega-amidase in the choroid plexus of rat brain (1993), J. Neurochem., 61, 1731-1741.
    View publication on PubMed
Search for more literature for 3.5.1.3

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
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 Rattus norvegicus 5737
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mitochondrion
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 Rattus norvegicus 5739
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additional information distribution Rattus norvegicus
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-
additional information liver, contains isozymic forms, mitochondrial and cytosolic, of omega-amidase Rattus norvegicus
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-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-oxoglutaramate + H2O Rattus norvegicus alpha-ketoglutaramate 2-oxoglutarate + NH3
-
 ?
2-oxosuccinamate + H2O Rattus norvegicus alpha-ketosuccinamate 2-oxosuccinate + NH3
-
 ?
additional information Rattus norvegicus second enzyme of the enzyme system capable of converting glutamine to ammonia and capable of generating relatively large amounts of ammonia from glutamine, the glutaminase II pathway, glutamine transaminase, EC 2.6.1.15 plus omega-amidase, EC 3.5.1.3 pathway ?
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 ?
additional information Rattus norvegicus role in cerebral glutamine metabolism ?
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 ?
additional information Rattus norvegicus high concentrations of omega-amidase in choroid plexus and in the S1-S3 region of nephron suggest that the glutaminase II pathway may generate appreciable ammonia locally in these organs, perhaps in association with transport ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 Sprague-Dawley rat
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Rattus norvegicus
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 contains isozymic forms, mitochondrial and cytosolic, of omega-amidase
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Source Tissue

Source Tissue Comment Organism Textmining
brain regional activities in brain Rattus norvegicus
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brain widespread in brain Rattus norvegicus
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choroid plexus highest activity in brain Rattus norvegicus
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kidney
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 Rattus norvegicus
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additional information omega-amidase is widespread, detected in various rat organs Rattus norvegicus
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additional information distribution in brain Rattus norvegicus
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nephron S1-S3 region of nephron Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoglutaramate + H2O alpha-ketoglutaramate Rattus norvegicus 2-oxoglutarate + NH3
-
 ?
2-oxosuccinamate + H2O alpha-ketosuccinamate Rattus norvegicus 2-oxosuccinate + NH3
-
 ?
additional information broad specificity Rattus norvegicus ?
-
 ?
additional information second enzyme of the enzyme system capable of converting glutamine to ammonia and capable of generating relatively large amounts of ammonia from glutamine, the glutaminase II pathway, glutamine transaminase, EC 2.6.1.15 plus omega-amidase, EC 3.5.1.3 pathway Rattus norvegicus ?
-
 ?
additional information role in cerebral glutamine metabolism Rattus norvegicus ?
-
 ?
additional information high concentrations of omega-amidase in choroid plexus and in the S1-S3 region of nephron suggest that the glutaminase II pathway may generate appreciable ammonia locally in these organs, perhaps in association with transport Rattus norvegicus ?
-
 ?