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Literature summary for 3.5.1.28 extracted from
- Quinolones with enhanced bactericidal activity induce autolysis in Streptococcus pneumoniae (2009), Chemotherapy, 55, 262-269.
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 35000 | - |
SDS-PAGE | Streptococcus pneumoniae |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptococcus pneumoniae | - |
strains R6 and TIGR4 and clinical isolate 033806 | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LytA | - |
Streptococcus pneumoniae |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Streptococcus pneumoniae | after 1 h of exposure to DC-159a and sitafloxacin, there is no significant increase in the expression of LytA | additional information |
| Streptococcus pneumoniae | after 2 h of exposure to twice the minimum inhibitory concentration, DC-159a increases the expression level of LytA by up to 3.6fold relative to the no drug control. Sitafloxacin induces expression of LytA by up to 4.6fold in S. pneumoniae strain R6 with 2 h of exposure to the minimum inhibitory concentration. Garenoxacin causes a less significant increase in LytA (up to 2.7fold at 2 h) than DC-159a and sitafloxacin | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | LytA is associated with the bactericidal activity of quinolones | Streptococcus pneumoniae |
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