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Literature summary for 3.5.1.26 extracted from
- Depletion of L-asparagine supply and apoptosis of leukemia cells induced by human glycosylasparaginase (2009), Leukemia, 23, 1167-1171.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | human glycosylasparaginase is a potential anticancer agent to induce apoptosis in L-asparagine-dependent cancer cells | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.538 | - |
N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine | at pH 7.5 and 37°C | Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| lysosome | - |
Homo sapiens | 5764 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | glycosylasparaginase hydrolyzes the N-glycosidic carbohydrate-to-protein linkage region, aspartylglucosamine, to L-aspartic acid and L-amino-N-acetylglucosamine through a reaction mechanism similar to L-asparaginase | Homo sapiens | ? | - |
? | |
| N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O | - |
Homo sapiens | 2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| aspartylglucosaminidase | - |
Homo sapiens |
| glycosylasparaginase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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