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Literature summary for 3.5.1.26 extracted from
- Comparison of liver glycosylasparaginases from six vertebrates (1992), Biochem. J., 282, 891-897.
General Stability
| General Stability | Organism |
|---|---|
| stable at higher pH values, stable in the presence of SDS | Gallus gallus |
| stable at higher pH values, stable in the presence of SDS | Mus musculus |
| stable at higher pH values, stable in the presence of SDS | Homo sapiens |
| stable at higher pH values, stable in the presence of SDS | Sus scrofa |
| stable at higher pH values, stable in the presence of SDS | Bos taurus |
| stable at higher pH values, stable in the presence of SDS | Rattus sp. |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 20000 | - |
alpha1, 1 * 24000 + beta1, 1 * 20000, SDS-PAGE | Homo sapiens |
| 24000 | - |
alpha1, 1 * 24000 + beta1, 1 * 20000, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O | Gallus gallus | - |
2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate | - |
? |  |
| N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O | Mus musculus | - |
2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate | - |
? | |
| N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O | Homo sapiens | - |
2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate | - |
? | |
| N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O | Sus scrofa | - |
2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate | - |
? | |
| N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O | Bos taurus | - |
2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate | - |
? | |
| N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O | Rattus sp. | - |
2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Gallus gallus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus sp. | - |
- |
- |
| Sus scrofa | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | each polypeptide N-glycosylated | Gallus gallus |
| glycoprotein | each polypeptide N-glycosylated | Mus musculus |
| glycoprotein | each polypeptide N-glycosylated | Homo sapiens |
| glycoprotein | each polypeptide N-glycosylated | Sus scrofa |
| glycoprotein | each polypeptide N-glycosylated | Bos taurus |
| glycoprotein | each polypeptide N-glycosylated | Rattus sp. |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Gallus gallus |
| partial | Mus musculus |
| partial | Homo sapiens |
| partial | Sus scrofa |
| partial | Bos taurus |
| partial | Rattus sp. |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Gallus gallus | - |
| liver | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Sus scrofa | - |
| liver | - |
Bos taurus | - |
| liver | - |
Rattus sp. | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.003 | - |
- |
Gallus gallus |
| 0.003 | - |
- |
Mus musculus |
| 0.003 | - |
- |
Homo sapiens |
| 0.003 | - |
- |
Sus scrofa |
| 0.003 | - |
- |
Bos taurus |
| 0.003 | - |
- |
Rattus sp. |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O | - |
Gallus gallus | 2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate | - |
? | |
| N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O | - |
Mus musculus | 2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate | - |
? | |
| N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O | - |
Homo sapiens | 2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate | - |
? | |
| N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O | - |
Sus scrofa | 2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate | - |
? | |
| N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O | - |
Bos taurus | 2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate | - |
? | |
| N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O | - |
Rattus sp. | 2-acetamido-1-amino-1,2-dideoxy-beta-D-glucose + L-aspartate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Mus musculus |
| dimer | - |
Sus scrofa |
| dimer | - |
Bos taurus |
| dimer | - |
Rattus sp. |
| dimer | alpha1, 1 * 24000 + beta1, 1 * 20000, SDS-PAGE | Homo sapiens |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 65 | 80 | irreversible inactivation | Gallus gallus |
| 65 | 80 | irreversible inactivation | Mus musculus |
| 65 | 80 | irreversible inactivation | Homo sapiens |
| 65 | 80 | irreversible inactivation | Sus scrofa |
| 65 | 80 | irreversible inactivation | Bos taurus |
| 65 | 80 | irreversible inactivation | Rattus sp. |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 6 | - |
Gallus gallus |
| 5.5 | 6 | - |
Homo sapiens |
| 5.5 | 6 | - |
Sus scrofa |
| 5.5 | 6 | - |
Bos taurus |
| 7 | 8 | - |
Mus musculus |
| 7 | 8 | - |
Rattus sp. |
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