Literature summary for 3.5.1.23 extracted from

Oizumi, A.; Nakayama, H.; Okino, N.; Iwahara, C.; Kina, K.; Matsumoto, R.; Ogawa, H.; Takamori, K.; Ito, M.; Suga, Y.; Iwabuchi, K.
Pseudomonas-derived ceramidase induces production of inflammatory mediators from human keratinocytes via sphingosine-1-phosphate (2014), PLoS ONE, 9, e89402.

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Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	-	isolated from a patient with Alzheimer's disease	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme is able to effectively degrade ceramide in the presence of Staphylococcus aureus-derived lipids or neutral detergents	Pseudomonas aeruginosa	?	-	?

Synonyms

Synonyms	Comment	Organism
neutral ceramidase	-	Pseudomonas aeruginosa
PaCDase	-	Pseudomonas aeruginosa

General Information

General Information	Comment	Organism
physiological function	the bacterial enzyme alone does not affect TNF-alpha gene expression in three-dimensionally cultured human primary keratinocytes. In the presence of the detergent Triton X-100, which damages stratum corneum structure, the active enzyme, but not heat-inactivated enzyme or inactive mutant enzyme, induces the production of TNF-alpha, endothelin-1, and interleukin-8, indicating that this production is dependent on ceramidase activity, it is also inhibited by a sphingosine kinase inhibitor and by an sphingosine 1-phosphate receptor antagonist VPC 23019. Among various ceramide metabolites, sphingosine and sphingosine 1-phosphate enhance the gene expression of TNF-alpha, endothelin-1, and interleukin-8, overview	Pseudomonas aeruginosa

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Release 2023.1 (January 2023)