Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q13510 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | enzyme expression vector, recombinant enzyme | Homo sapiens | - |
DU-145 cell | - |
Homo sapiens | - |
prostate | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
acid ceramidase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | leptomycin B prevents acid ceramidase and sphingosine 1-phosphate mediated loss of nuclear PTEN, suggesting an active exportin-mediated event | Homo sapiens |
physiological function | tumor promotion of acid ceramidase in prostate cancer. Impact of acid ceramidase on the nuclear-cytoplasmic trafficking of tumor suppressor PTEN, immunohistochemical analysis, overview. Acid ceramidase, through sphingosine 1-phosphate, promotes nuclear export of PTEN as a means of promoting tumor formation, cell proliferation, and resistance to therapy. Acid ceramidase promotes a reduction in nuclear PTEN that is dependent upon sphingosine 1-phosphate-mediated activation of Akt | Homo sapiens |