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Literature summary for 3.5.1.23 extracted from

  • Lucki, N.C.; Li, D.; Bandyopadhyay, S.; Wang, E.; Merrill, A.H.; Sewer, M.B.
    Acid ceramidase (ASAH1) represses steroidogenic factor 1-dependent gene transcription in H295R human adrenocortical cells by binding to the receptor (2012), Mol. Cell. Biol., 32, 4419-4431.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.23

Cloned(Commentary)

Cloned (Comment) Organism
gene ASAH1, in vitro translation of FLAG-tagged enzyme from the pCMV6-XL5-ASAH1 plasmid and transient expression in H295R cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13510 gene ASAH1
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenocortical carcinoma cell line
-
 Homo sapiens
-
NCI-H295R cell the enzyme is localized in the nuclei of H295R adrenocortical cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme directly interacts with and binds steroidogenic factor 1, interaction site analysis, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
acid ceramidase
-
 Homo sapiens
ASAH1
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme overexpression attenuates steroidogenic factor 1-stimulated CYP17A1 reporter gene activity. The enzyme not only abrogates Bt2cAMP-dependent CYP17A1 reporter gene activity but also inhibits SF-1-stimulated CYP17A1 reporter gene activity in both untreated and Bt2cAMP-stimulated cells Homo sapiens
metabolism ACTH/cAMP signaling promotes nuclear sphingolipid metabolism in an enzyme-dependent manner. ACTH/cAMP signaling promotes the recruitment of the enzyme to multiple steroidogenic gene promoters Homo sapiens
physiological function nuclear receptor steroidogenic factor 1 is essential for steroidogenic gene transcription. Acid ceramidase represses nuclear receptor steroidogenic factor 1-dependent gene transcription in H295R human adrenocortical cells by binding to the receptor, molecular mechanism, overview. The enzyme is a coregulatory protein that represses steroidogenic factor 1 function by directly binding to the receptor on steroidogenic factor 1 target gene promoters and plays a key role for nuclear lipid metabolism in regulating gene transcription Homo sapiens