Cloned (Comment) | Organism |
---|---|
recombinant expression of V5/His-tagged enzyme using vector pEF6-V5/His in HEK-293 cells | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1R,2R)-2-(N-tetradecanoylamino)-1-(4-nitrophenyl)-1,3-propanediol | - |
Rattus norvegicus | |
(1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol | - |
Rattus norvegicus | |
3-(cyclopropylmethyl)-5-fluoro-N-hexyl-2,4-dioxopyrimidine-1-carboxamide | - |
Rattus norvegicus | |
3-benzoyl-5-fluoro-N-hexyl-2,4-dioxopyrimidine-1-carboxamide | - |
Rattus norvegicus | |
3-ethyl-5-fluoro-N-hexyl-2,4-dioxopyrimidine-1-carboxamide | - |
Rattus norvegicus | |
5-(benzyl(methyl)amino)-N-hexyl-2,4-dioxopyrimidine-1-carboxamide | - |
Rattus norvegicus | |
5-chloro-N-hexyl-2,4-dioxo-3,4-dihydropyrimidine-1(2H)-carboxamide | - |
Rattus norvegicus | |
5-cyano-N-hexyl-2,4-dioxo-3,4-dihydropyrimidine-1(2H)-carboxamide | - |
Rattus norvegicus | |
5-ethyl-N-hexyl-2,4-dioxopyrimidine-1-carboxamide | - |
Rattus norvegicus | |
5-fluoro-N-hexyl-2,4-dioxo-3,4-dihydropyrimidine-1(2H)-carboxamide | - |
Rattus norvegicus | |
5-fluoro-N-hexyl-3-(2-methylpropanoyl)-2,4-dioxopyrimidine-1-carboxamide | - |
Rattus norvegicus | |
5-fluoro-N-hexyl-3-methyl-2,4-dioxopyrimidine-1-carboxamide | - |
Rattus norvegicus | |
5-fluoro-N-octyl-2,4-dioxopyrimidine-1-carboxamide | - |
Rattus norvegicus | |
6-chloro-N-hexyl-2,4-dioxo-3,4-dihydropyrimidine-1(2H)-carboxamide | - |
Rattus norvegicus | |
carmofur | - |
Rattus norvegicus | |
ethyl 5-fluoro-3-(hexylcarbamoyl)-2,6-dioxopyrimidine-1-carboxylate | - |
Rattus norvegicus | |
isobutyl 5-fluoro-3-(hexylcarbamoyl)-2,6-dioxopyrimidine-1-carboxylate | - |
Rattus norvegicus | |
methyl 5-fluoro-3-(hexylcarbamoyl)-2,6-dioxopyrimidine-1-carboxylate | - |
Rattus norvegicus | |
methyl 5-fluoro-3-(octylcarbamoyl)-2,6-dioxopyrimidine-1-carboxylate | - |
Rattus norvegicus | |
additional information | synthesis and evaluation of a series of 2,4-dioxopyrimidine-1-carboxamides as acid ceramidase enzyme inhibitors, structural features of uracil derivatives that are critical for inhibition, overview. No inhibition by 7 and 27b, while 4o, 26 and 30 are unstable | Rattus norvegicus | |
N-butyl-2,4-dioxopyrimidine-1-carboxamide | - |
Rattus norvegicus | |
N-heptyl-2,4-dioxopyrimidine-1-carboxamide | - |
Rattus norvegicus | |
N-hexyl-2,4-dioxo-3,4-dihydropyrimidine-1(2H)-carboxamide | - |
Rattus norvegicus | |
N-hexyl-2,4-dioxo-5-(trifluoromethyl)-3,4-dihydropyrimidine-1(2H)-carboxamide | - |
Rattus norvegicus | |
N-hexyl-2,4-dioxo-5-phenylpyrimidine-1-carboxamide | - |
Rattus norvegicus | |
N-hexyl-2,4-dioxohexahydropyrimidine-1-carboxamide | - |
Rattus norvegicus | |
N-hexyl-3-methyl-2,4-dioxopyrimidine-1-carboxamide | - |
Rattus norvegicus | |
N-hexyl-5,6-dimethyl-2,4-dioxo-3,4-dihydropyrimidine-1(2H)-carboxamide | - |
Rattus norvegicus | |
N-hexyl-5-(4-methylpiperazin-1-yl)-2,4-dioxopyrimidine-1-carboxamide | - |
Rattus norvegicus | |
N-hexyl-5-(hydroxymethyl)-2,4-dioxopyrimidine-1-carboxamide | - |
Rattus norvegicus | |
N-hexyl-5-bromo-2,4-dioxopyrimidine-1-carboxamide | - |
Rattus norvegicus | |
N-hexyl-5-iodo-2,4-dioxopyrimidine-1-carboxamide | - |
Rattus norvegicus | |
N-hexyl-5-methoxy-2,4-dioxopyrimidine-1-carboxamide | - |
Rattus norvegicus | |
N-hexyl-5-methyl-2,4-dioxo-3,4-dihydropyrimidine-1(2H)-carboxamide | - |
Rattus norvegicus | |
N-hexyl-5-methylamino-2,4-dioxopyrimidine-1-carboxamide | - |
Rattus norvegicus | |
N-hexyl-5-morpholino-2,4-dioxopyrimidine-1-carboxamide | - |
Rattus norvegicus | |
N-hexyl-N-methyl-2,4-dioxopyrimidine-1-carboxamide | - |
Rattus norvegicus | |
N-nonyl-2,4-dioxopyrimidine-1-carboxamide | - |
Rattus norvegicus | |
N-octyl-2,4-dioxo-5-(trifluoromethyl)pyrimidine-1-carboxamide | - |
Rattus norvegicus | |
N-octyl-2,4-dioxopyrimidine-1-carboxamide | - |
Rattus norvegicus | |
N-pentyl-2,4-dioxopyrimidine-1-carboxamide | - |
Rattus norvegicus | |
oleoylethanolamide | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
intracellular | - |
Rattus norvegicus | 5622 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | Q6P7S1 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-lauroylceramide + H2O | - |
Rattus norvegicus | laureate + sphingosine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acid ceramidase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4.5 | - |
assay at | Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000004 | - |
pH 4.5, 37°C | Rattus norvegicus | methyl 5-fluoro-3-(octylcarbamoyl)-2,6-dioxopyrimidine-1-carboxylate | |
0.0000046 | - |
pH 4.5, 37°C | Rattus norvegicus | 5-fluoro-N-octyl-2,4-dioxopyrimidine-1-carboxamide | |
0.000007 | - |
pH 4.5, 37°C | Rattus norvegicus | methyl 5-fluoro-3-(hexylcarbamoyl)-2,6-dioxopyrimidine-1-carboxylate | |
0.000007 | - |
pH 4.5, 37°C | Rattus norvegicus | N-octyl-2,4-dioxo-5-(trifluoromethyl)pyrimidine-1-carboxamide | |
0.000012 | - |
pH 4.5, 37°C | Rattus norvegicus | ethyl 5-fluoro-3-(hexylcarbamoyl)-2,6-dioxopyrimidine-1-carboxylate | |
0.000012 | - |
pH 4.5, 37°C | Rattus norvegicus | N-hexyl-2,4-dioxo-5-(trifluoromethyl)-3,4-dihydropyrimidine-1(2H)-carboxamide | |
0.000013 | - |
pH 4.5, 37°C | Rattus norvegicus | 5-fluoro-N-hexyl-3-methyl-2,4-dioxopyrimidine-1-carboxamide | |
0.000016 | - |
pH 4.5, 37°C | Rattus norvegicus | isobutyl 5-fluoro-3-(hexylcarbamoyl)-2,6-dioxopyrimidine-1-carboxylate | |
0.000018 | - |
pH 4.5, 37°C | Rattus norvegicus | 3-ethyl-5-fluoro-N-hexyl-2,4-dioxopyrimidine-1-carboxamide | |
0.00002 | - |
pH 4.5, 37°C | Rattus norvegicus | 3-benzoyl-5-fluoro-N-hexyl-2,4-dioxopyrimidine-1-carboxamide | |
0.000021 | - |
pH 4.5, 37°C | Rattus norvegicus | 5-fluoro-N-hexyl-3-(2-methylpropanoyl)-2,4-dioxopyrimidine-1-carboxamide | |
0.000029 | - |
pH 4.5, 37°C | Rattus norvegicus | 5-fluoro-N-hexyl-2,4-dioxo-3,4-dihydropyrimidine-1(2H)-carboxamide | |
0.000029 | - |
pH and temperature not specified in the publication | Rattus norvegicus | carmofur | |
0.0000325 | - |
pH 4.5, 37°C | Rattus norvegicus | N-heptyl-2,4-dioxopyrimidine-1-carboxamide | |
0.000051 | - |
pH 4.5, 37°C | Rattus norvegicus | N-hexyl-5-bromo-2,4-dioxopyrimidine-1-carboxamide | |
0.000053 | - |
pH 4.5, 37°C | Rattus norvegicus | N-hexyl-3-methyl-2,4-dioxopyrimidine-1-carboxamide | |
0.000061 | - |
pH 4.5, 37°C | Rattus norvegicus | 3-(cyclopropylmethyl)-5-fluoro-N-hexyl-2,4-dioxopyrimidine-1-carboxamide | |
0.000067 | - |
pH 4.5, 37°C | Rattus norvegicus | 5-chloro-N-hexyl-2,4-dioxo-3,4-dihydropyrimidine-1(2H)-carboxamide | |
0.000147 | - |
pH 4.5, 37°C | Rattus norvegicus | N-hexyl-5-iodo-2,4-dioxopyrimidine-1-carboxamide | |
0.000177 | - |
pH 4.5, 37°C | Rattus norvegicus | N-hexyl-2,4-dioxo-5-phenylpyrimidine-1-carboxamide | |
0.000283 | - |
pH 4.5, 37°C | Rattus norvegicus | N-octyl-2,4-dioxopyrimidine-1-carboxamide | |
0.000417 | - |
pH 4.5, 37°C | Rattus norvegicus | N-hexyl-5-(hydroxymethyl)-2,4-dioxopyrimidine-1-carboxamide | |
0.000426 | - |
pH 4.5, 37°C | Rattus norvegicus | N-hexyl-2,4-dioxo-3,4-dihydropyrimidine-1(2H)-carboxamide | |
0.000464 | - |
pH 4.5, 37°C | Rattus norvegicus | N-nonyl-2,4-dioxopyrimidine-1-carboxamide | |
0.000733 | - |
pH 4.5, 37°C | Rattus norvegicus | 5-ethyl-N-hexyl-2,4-dioxopyrimidine-1-carboxamide | |
0.000875 | - |
pH 4.5, 37°C | Rattus norvegicus | N-hexyl-5-morpholino-2,4-dioxopyrimidine-1-carboxamide | |
0.0011 | - |
pH 4.5, 37°C | Rattus norvegicus | N-hexyl-5-methoxy-2,4-dioxopyrimidine-1-carboxamide | |
0.0014 | - |
pH 4.5, 37°C | Rattus norvegicus | N-hexyl-5-(4-methylpiperazin-1-yl)-2,4-dioxopyrimidine-1-carboxamide | |
0.00146 | - |
pH 4.5, 37°C | Rattus norvegicus | N-hexyl-5-methyl-2,4-dioxo-3,4-dihydropyrimidine-1(2H)-carboxamide | |
0.0021 | - |
pH 4.5, 37°C | Rattus norvegicus | N-pentyl-2,4-dioxopyrimidine-1-carboxamide | |
0.0034 | - |
pH 4.5, 37°C | Rattus norvegicus | N-hexyl-5-methylamino-2,4-dioxopyrimidine-1-carboxamide | |
0.0055 | - |
pH 4.5, 37°C | Rattus norvegicus | 5-(benzyl(methyl)amino)-N-hexyl-2,4-dioxopyrimidine-1-carboxamide | |
0.0085 | - |
pH 4.5, 37°C | Rattus norvegicus | N-butyl-2,4-dioxopyrimidine-1-carboxamide |