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Literature summary for 3.5.1.23 extracted from
- Novel amide- and sulfonamide-based aromatic ethanolamines: Effects of various substituents on the inhibition of acid and neutral ceramidases (2012), Bioorg. Med. Chem., 20, 6162-6170.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| recombinant expression in Spodoptera frugiperda Sf9 cells | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (1R,2R)-2-(N-tetradecanoylamino)-1-(4-nitrophenyl)-1,3-propanediol | - |
Homo sapiens |  |
| (1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol | - |
Homo sapiens | |
| additional information | amide- and sulfonamide-based compounds as potential inhibitors of ceramidases, synthesis and inhibitory potencies, overview. The hydrophobicity and the steric effects of longer alkyl chains (n-Pr, n-Bu or t-Bu groups) at the phenyl ring are important for an enhanced selectivity towards acid ceramidase over neutral ceramidase | Homo sapiens | |
| N-(2-hydroxy-2-phenylethyl)dodecane-1-sulfonamide | - |
Homo sapiens | |
| N-(2-hydroxy-2-phenylethyl)tetradecanamide | - |
Homo sapiens | |
| N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]dodecane-1-sulfonamide | - |
Homo sapiens | |
| N-[(1S,2R)-1-hydroxy-1-(4-nitrophenyl)propan-2-yl]dodecane-1-sulfonamide | - |
Homo sapiens | |
| N-[(2R)-2-hydroxy-2-(4-methylphenyl)ethyl]tetradecanamide | - |
Homo sapiens | |
| N-[(2S)-2-hydroxy-2-(4-methylphenyl)ethyl]tetradecanamide | - |
Homo sapiens | |
| N-[2-(4-butylphenyl)-2-hydroxyethyl]tetradecanamide | - |
Homo sapiens | |
| N-[2-(4-ethylphenyl)-2-hydroxyethyl]tetradecanamide | - |
Homo sapiens | |
| N-[2-(4-fluorophenyl)-2-hydroxyethyl]tetradecanamide | - |
Homo sapiens | |
| N-[2-(4-tert-butylphenyl)-2-hydroxyethyl]tetradecanamide | - |
Homo sapiens | |
| N-[2-hydroxy-2-(3-hydroxyphenyl)ethyl]tetradecanamide | - |
Homo sapiens | |
| N-[2-hydroxy-2-(3-methoxyphenyl)ethyl]tetradecanamide | - |
Homo sapiens | |
| N-[2-hydroxy-2-(3-methylphenyl)ethyl]tetradecanamide | - |
Homo sapiens | |
| N-[2-hydroxy-2-(4-hydroxyphenyl)ethyl]tetradecanamide | - |
Homo sapiens | |
| N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]tetradecanamide | - |
Homo sapiens | |
| N-[2-hydroxy-2-(4-methylphenyl)ethyl]dodecane-1-sulfonamide | - |
Homo sapiens | |
| N-[2-hydroxy-2-(4-methylphenyl)ethyl]tetradecanamide | - |
Homo sapiens | |
| N-[2-hydroxy-2-(4-propylphenyl)ethyl]tetradecanamide | - |
Homo sapiens | |
| N-[2-hydroxy-2-(pyridin-3-yl)ethyl]dodecane-1-sulfonamide | - |
Homo sapiens | |
| N-[2-hydroxy-2-(pyridin-4-yl)ethyl]dodecane-1-sulfonamide | - |
Homo sapiens | |
| N-[2-hydroxy-2-(pyridin-4-yl)ethyl]tetradecanamide | - |
Homo sapiens | |
| oleoylethanolamide | i.e. N-oleylethanolamine; i.e. N-oleylethanolamine | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q13510 | - |
- |
| Homo sapiens | Q9NR71 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant enzyme partially from SF9 cells | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | recombinant enzyme | Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| aCDase | - |
Homo sapiens |
| acid ceramidase | - |
Homo sapiens |
| ASAH1 | - |
Homo sapiens |
| ASAH2 | - |
Homo sapiens |
| N-acylsphingosine amidohydrolase 2 | - |
Homo sapiens |
| nCDase | - |
Homo sapiens |
| neutral ceramidase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 4.5 | - |
assay at | Homo sapiens |
| 7 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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