Application | Comment | Organism |
---|---|---|
medicine | inhibition of acid ceramidase is useful in cancer treatment | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in CHO cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1R,2R)-2-N-myristoylamino-1-(4-nitrophenyl)-1,3-propandiol | - |
Homo sapiens | |
(1R,2R)-2-N-myristoylamino-1-(4-nitrophenyl)-1,3-propandiol | - |
Mus musculus | |
(1S,2R)-2-N-myristoylamino-1-phenyl-1-propanol | - |
Homo sapiens | |
(1S,2R)-2-N-myristoylamino-1-phenyl-1-propanol | - |
Mus musculus | |
1R,2R-(2-N-myristoylamino-1-(4-nitrophenyl)-1,3-dihydroxypropane) | - |
Homo sapiens | |
1R,2R-(2-N-myristoylamino-1-(4-nitrophenyl)-1,3-dihydroxypropane) | - |
Mus musculus | |
1S,2S-(2-N-myristoylamino-1-(4-nitrophenyl)-1,3-dihydroxypropane) | - |
Homo sapiens | |
1S,2S-(2-N-myristoylamino-1-(4-nitrophenyl)-1,3-dihydroxypropane) | - |
Mus musculus | |
N-oleoylethanolamine | - |
Homo sapiens | |
N-oleoylethanolamine | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Mus musculus | 5764 | - |
lysosome | - |
Homo sapiens | 5764 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
13000 | - |
x * 40000 + 1 * 13000 | Homo sapiens |
40000 | - |
x * 40000 + 1 * 13000 | Homo sapiens |
53000 | - |
- |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ceramide + H2O | Mus musculus | - |
sphingosine + fatty acid | - |
r | |
ceramide + H2O | Homo sapiens | - |
sphingosine + fatty acid | - |
r | |
N-lauroylsphingosine + H2O | Homo sapiens | - |
laurate + sphingosine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Mus musculus |
glycoprotein | - |
Homo sapiens |
Purification (Comment) | Organism |
---|---|
concanavalin A column chromatography, Blue Sepharose column chromatography, and Superose 12 gel filtration | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
oocyte | acid ceramidase protein is observed in unfertilized eggs | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ceramide + H2O | - |
Mus musculus | sphingosine + fatty acid | - |
r | |
ceramide + H2O | - |
Homo sapiens | sphingosine + fatty acid | - |
r | |
N-lauroylsphingosine + H2O | - |
Homo sapiens | laurate + sphingosine | - |
? |
Subunits | Comment | Organism |
---|---|---|
heterodimer | x * 40000 + 1 * 13000 | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
acid ceramidase | - |
Mus musculus |
acid ceramidase | - |
Homo sapiens |
N-acylsphingosine deacylase | - |
Mus musculus |
N-acylsphingosine deacylase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Mus musculus | acid ceramidase protein and mRNA are decreased during egg aging | down |
Homo sapiens | significantly decreased ceramide levels are observed in human colon cancers, gliomas, ovarian cancers, thyroid and gastrointestinal cancers | down |
General Information | Comment | Organism |
---|---|---|
malfunction | inhibition of acid ceramidase activity stimulates apoptotic cell death. Point mutations in the acid ceramidase gene cause rare autosomal recessive Farber disease. Homozygous acid ceramidase-deficient mice are embryonic lethal | Mus musculus |
physiological function | the enzyme determines cell fate, namely, death or survival, by controlling the balance between the intracellular levels of ceramide and sphingosine 1-phosphate. Acid ceramidase plays an important role in tumorigenesis and in prolonging the survival of cells | Homo sapiens |