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Literature summary for 3.5.1.23 extracted from

  • Claus, R.A.; Dorer, M.J.; Bunck, A.C.; Deigner, H.P.
    Inhibition of sphingomyelin hydrolysis: targeting the lipid mediator ceramide as a key regulator of cellular fate (2009), Curr. Med. Chem., 16, 1978-2000.
    View publication on PubMed
Search for more literature for 3.5.1.23

Inhibitors

Inhibitors Comment Organism Structure
desipramine acid ceramidase Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome acid ceramidase Homo sapiens 5764
-
membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ceramide + H2O Homo sapiens for ceramide clearance, ceramidases hydrolyze the N-acyl fatty acid, yielding in the generation of sphingosine sphingosine + fatty acid
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiomyocyte
-
 Homo sapiens
-
heart
-
 Homo sapiens
-
myocardium
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ceramide + H2O
-
 Homo sapiens sphingosine + fatty acid
-
 ?
ceramide + H2O for ceramide clearance, ceramidases hydrolyze the N-acyl fatty acid, yielding in the generation of sphingosine Homo sapiens sphingosine + fatty acid
-
 ?

General Information

General Information Comment Organism
metabolism the enzyme is one of the key players, which determine the dynamic balance between the intracellular levels of ceramide and its breakdown products, in ceramide metabolism and sphingolipid biosynthesis, metabolism and interconversions, overview Homo sapiens
additional information ceramidase inhibition abolishes contractile effects in cardiomyocytes Homo sapiens