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Literature summary for 3.5.1.23 extracted from

  • Acharya, J.K.; Dasgupta, U.; Rawat, S.S.; Yuan, C.; Sanxaridis, P.D.; Yonamine, I.; Karim, P.; Nagashima, K.; Brodsky, M.H.; Tsunoda, S.; Acharya, U.
    Cell-nonautonomous function of ceramidase in photoreceptor homeostasis (2008), Neuron, 57, 69-79.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.23

Inhibitors

Inhibitors Comment Organism Structure
CDase specific RNAi
-
 Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome
-
 Drosophila melanogaster 5768
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ceramide + H2O Drosophila melanogaster
-
 sphingosine + fatty acid
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster Q9VA70
-
-

Source Tissue

Source Tissue Comment Organism Textmining
retina
-
 Drosophila melanogaster
-
S2 cell
-
 Drosophila melanogaster
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00052
-
 control w1118 fly Drosophila melanogaster
0.00125
-
 CDase null mutant and CDase null expressing fat body driven CDase Drosophila melanogaster

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
C12-4-nitrobenzo-2-oxa-1,3-diazole-ceramide + H2O substrate activity assay Drosophila melanogaster ?
-
 ?
ceramide + H2O
-
 Drosophila melanogaster sphingosine + fatty acid
-
 ?
palmitoyl sphingosine + H2O substrate activity assay Drosophila melanogaster palmitate + sphingosine
-
 ?

Synonyms

Synonyms Comment Organism
CDase
-
 Drosophila melanogaster
ceramidase
-
 Drosophila melanogaster
neutral ceramidase
-
 Drosophila melanogaster