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Literature summary for 3.5.1.23 extracted from

  • Park, J.; Schuchman, E.H.
    Acid ceramidase and human disease (2006), Biochim. Biophys. Acta, 1758, 2133-2138.
    View publication on PubMed

Application

Application Comment Organism
medicine Farber disease is diagnosed by the demonstration of reduced acid ceramidase activity, abnormally high ceramide levels in cultured cells, biopsy samples or urine, and the presence of Farber bodies, comma-shaped curvilinear tubular structures. The enzyme is likely to continue to be a target for new drug development in cancer and other disorders Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in CHO cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens acid ceramidase plays a critical role in the regulation of ceramide and sphingosine metabolism ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pituitary gland
-
Homo sapiens
-
skin fibroblast
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information acid ceramidase plays a critical role in the regulation of ceramide and sphingosine metabolism Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
acid ceramidase
-
Homo sapiens
N-acylsphingosine deacylase
-
Homo sapiens