Application | Comment | Organism |
---|---|---|
medicine | Farber disease is diagnosed by the demonstration of reduced acid ceramidase activity, abnormally high ceramide levels in cultured cells, biopsy samples or urine, and the presence of Farber bodies, comma-shaped curvilinear tubular structures. The enzyme is likely to continue to be a target for new drug development in cancer and other disorders | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
overexpression in CHO cells | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | acid ceramidase plays a critical role in the regulation of ceramide and sphingosine metabolism | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pituitary gland | - |
Homo sapiens | - |
skin fibroblast | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | acid ceramidase plays a critical role in the regulation of ceramide and sphingosine metabolism | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acid ceramidase | - |
Homo sapiens |
N-acylsphingosine deacylase | - |
Homo sapiens |