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Literature summary for 3.5.1.23 extracted from
- Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis (2006), J. Lipid Res., 47, 1063-1070.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression analysis of isozymes during keratinocyte differentiation, expression levels in undifferentiated, early-stage and advanced-stage cells, and in whole epidermis by RT-PCR | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | acidic and alkaline isozyme activities increase with keratinocyte differentiation, while the activities of phytoalkaline and neutral isozymes decrease, overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q5QJU3 | five isozymes: acid, neutral, phytoalkaline, and alkaline-1 and -2 isozymes | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| epidermis | differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis, distribution of acid and alkaline isozymes, overview | Homo sapiens | - |
| foreskin | of newborn | Homo sapiens | - |
| heart | - |
Homo sapiens | - |
| keratinocyte | differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis | Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| lung | - |
Homo sapiens | - |
| additional information | isozyme tissue distribution, alkaline isozyme 1 is active for epidermis, small intestine, and thymus, all other isozymes are abundant, overview | Homo sapiens | - |
| small intestine | - |
Homo sapiens | - |
| stratum corneum | - |
Homo sapiens | - |
| thymus | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
relative activities of isozymes during keratinocyte differentiation, tissue distribution of isozymes expression levels, overview | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-nitrobenzo-2-oxa-1,3-diazole-C12-ceramide + H2O | - |
Homo sapiens | 4-nitrobenzo-2-oxa-1,3-diazole-dodecanoic acid + ceramide | - |
? | |
| additional information | acidic and alkaline isozyme activities increase with keratinocyte differentiation, while the activities of phytoalkaline and neutral isozymes decrease, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| aCDase | - |
Homo sapiens |
| acid ceramidase | - |
Homo sapiens |
| alkaline ceramidase | - |
Homo sapiens |
| alkCDase-1 | - |
Homo sapiens |
| alkCDase-2 | - |
Homo sapiens |
| CDase | - |
Homo sapiens |
| nCDase | - |
Homo sapiens |
| neutral ceramidase | - |
Homo sapiens |
| phytoalkaline ceramidase | - |
Homo sapiens |
| phytoCDase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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