Application | Comment | Organism |
---|---|---|
medicine | purified L-glutaminase has a high toxic effect on Hela and Hep G2 cell lines with an IC50 value 18 and 12 microg/ml, respectively, and a moderate cytotoxic effect on HCT-116 and MCF7 cells, with an IC50 value 44 and 58 microg/ml, respectively | Aspergillus flavus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | 10 mM, 80% of initial activity | Aspergillus flavus | |
Cu2+ | 10 mM, 44% of initial activity | Aspergillus flavus | |
Hg2+ | 10 mM, 35% of initial activity | Aspergillus flavus | |
iodoacetate | 10 mM, 23% of initial activity | Aspergillus flavus | |
Mg2+ | 10 mM, 55% of initial activity | Aspergillus flavus | |
N-ethylmaleimide | 10 mM, 60% of initial activity | Aspergillus flavus | |
Zn2+ | 10 mM, 30% of initial activity | Aspergillus flavus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
4.5 | - |
L-glutamine | pH 7.0, 30°C | Aspergillus flavus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Na+ | 10 mM, 129% of initial activity | Aspergillus flavus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aspergillus flavus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Aspergillus flavus |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
613.3 | - |
pH 7.0, 30°C | Aspergillus flavus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-albizziin + H2O | - |
Aspergillus flavus | ? + NH3 | - |
? | |
L-asparagine + H2O | - |
Aspergillus flavus | L-aspartate + NH3 | - |
? | |
L-glutamine + H2O | - |
Aspergillus flavus | L-glutamate + NH3 | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 69000, SDS-PAGE | Aspergillus flavus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
40 | - |
- |
Aspergillus flavus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
- |
Aspergillus flavus |