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Literature summary for 3.5.1.2 extracted from

  • Prokop, M.; Czarnecka, J.; Milewska, M.
    Ngamma-alkyl derivatives of L-glutamine as inhibitors of glutamine-utilizing enzymes (2009), Z. Naturforsch. C, 64, 631-636.
    View publication on PubMed
Search for more literature for 3.5.1.2

Inhibitors

Inhibitors Comment Organism Structure
Ngamma,Ngamma-diethyl-L-glutamine
-
 Escherichia coli
Ngamma,Ngamma-dimethyl-L-glutamine
-
 Escherichia coli
Ngamma-ethyl-L-glutamine
-
 Escherichia coli
Ngamma-methyl-L-glutamine
-
 Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 commercial preparation
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Escherichia coli
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamine + H2O
-
 Escherichia coli L-glutamate + NH3
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.11
-
 Ngamma-methyl-L-glutamine 37°C, pH 7.5 Escherichia coli
1.58
-
 Ngamma-ethyl-L-glutamine 37°C, pH 7.5 Escherichia coli
2.64
-
 Ngamma,Ngamma-dimethyl-L-glutamine 37°C, pH 7.5 Escherichia coli
2.95
-
 Ngamma,Ngamma-diethyl-L-glutamine 37°C, pH 7.5 Escherichia coli

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
20
-
 37°C, pH 7.5 Escherichia coli Ngamma-methyl-L-glutamine
24
-
 37°C, pH 7.5 Escherichia coli Ngamma-ethyl-L-glutamine
35
-
 37°C, pH 7.5 Escherichia coli Ngamma,Ngamma-dimethyl-L-glutamine
39
-
 37°C, pH 7.5 Escherichia coli Ngamma,Ngamma-diethyl-L-glutamine