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Literature summary for 3.5.1.2 extracted from

  • Buschdorf, J.P.; Li Chew, L.; Zhang, B.; Cao, Q.; Liang, F.Y.; Liou, Y.C.; Zhou, Y.T.; Low, B.C.
    Brain-specific BNIP-2-homology protein Caytaxin relocalises glutaminase to neurite terminals and reduces glutamate levels (2006), J. Cell Sci., 119, 3337-3350.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of FLAG-tagged KGA in 293T cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
protein BNIP-H i.e. Caytaxin or brain-specific BNIP-2-homology protein, encoded by gene ATCAY, important in neuromal function, inhibits the enzyme and alters its steady-state kinetics, relocalises glutaminase to neurite terminals and reduces glutamate levels in vivo, effects on glutamate levels in overexpressing cell lines, e.g. murine Neuro2A cells or rat PC-12 cells, or in female rat brain, detailed overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion isozyme KGA Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutamine + H2O Homo sapiens glutamate is an important source for neurotransmitter L-glutamate + NH3
-
?
additional information Homo sapiens the brain-specific BNIP-2-homology protein, BHIP-H is involved in enzyme regulation in neurons, loss of BNIP-H function could render glutamate excitotoxicity or/and deregulated glutamatergic activation, leading to ataxia, dystonia or other neurological disorders ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens O94925 kidney-type glutaminase isozyme
-

Source Tissue

Source Tissue Comment Organism Textmining
brain isozyme KGA Homo sapiens
-
neuron isozyme KGA Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamine + H2O
-
Homo sapiens L-glutamate + NH3
-
?
L-glutamine + H2O glutamate is an important source for neurotransmitter Homo sapiens L-glutamate + NH3
-
?
additional information the brain-specific BNIP-2-homology protein, BHIP-H is involved in enzyme regulation in neurons, loss of BNIP-H function could render glutamate excitotoxicity or/and deregulated glutamatergic activation, leading to ataxia, dystonia or other neurological disorders Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
GLS
-
Homo sapiens
K-glutaminase
-
Homo sapiens
KGA
-
Homo sapiens
kidney-type glutaminase
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens