Cloned (Comment) | Organism |
---|---|
expression of FLAG-tagged KGA in 293T cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
protein BNIP-H | i.e. Caytaxin or brain-specific BNIP-2-homology protein, encoded by gene ATCAY, important in neuromal function, inhibits the enzyme and alters its steady-state kinetics, relocalises glutaminase to neurite terminals and reduces glutamate levels in vivo, effects on glutamate levels in overexpressing cell lines, e.g. murine Neuro2A cells or rat PC-12 cells, or in female rat brain, detailed overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | isozyme KGA | Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-glutamine + H2O | Homo sapiens | glutamate is an important source for neurotransmitter | L-glutamate + NH3 | - |
? | |
additional information | Homo sapiens | the brain-specific BNIP-2-homology protein, BHIP-H is involved in enzyme regulation in neurons, loss of BNIP-H function could render glutamate excitotoxicity or/and deregulated glutamatergic activation, leading to ataxia, dystonia or other neurological disorders | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O94925 | kidney-type glutaminase isozyme | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | isozyme KGA | Homo sapiens | - |
neuron | isozyme KGA | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-glutamine + H2O | - |
Homo sapiens | L-glutamate + NH3 | - |
? | |
L-glutamine + H2O | glutamate is an important source for neurotransmitter | Homo sapiens | L-glutamate + NH3 | - |
? | |
additional information | the brain-specific BNIP-2-homology protein, BHIP-H is involved in enzyme regulation in neurons, loss of BNIP-H function could render glutamate excitotoxicity or/and deregulated glutamatergic activation, leading to ataxia, dystonia or other neurological disorders | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GLS | - |
Homo sapiens |
K-glutaminase | - |
Homo sapiens |
KGA | - |
Homo sapiens |
kidney-type glutaminase | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |