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Literature summary for 3.5.1.2 extracted from
- Properties of rat renal phosphate-dependent glutaminase coupled to Sepharose. Evidence that dimerization is essential for activation (1981), Biochem. J., 193, 709-716.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| NH4+ | addition of phosphate results in dimerization and activation | Rattus norvegicus |  |
| phosphate | - |
Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| diazo-5-oxo-L-norleucine | inactivates dimeric enzyme form in presence or absence of phosphate | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Gln + H2O | - |
Rattus norvegicus | Glu + NH3 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | in absence of phosphate the enzyme exists as an inactive protomer, addition of phosphate results in activation and dimerization | Rattus norvegicus |
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