Crystallization (Comment) | Organism |
---|---|
crystal structure (PDB ID 2WT9) analysis, and modeling of substrate binding and unbinding, overview | Acinetobacter baumannii |
crystal structure (PDB ID 3O94) analysis, and modeling of substrate binding and unbinding, overview | Streptococcus pneumoniae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
nicotinamide + H2O | Streptococcus pneumoniae | - |
nicotinate + NH3 | - |
? | |
nicotinamide + H2O | Acinetobacter baumannii | - |
nicotinate + NH3 | - |
? | |
pyrazinamide + H2O | Streptococcus pneumoniae | - |
pyrazinoic acid + NH3 | - |
? | |
pyrazinamide + H2O | Acinetobacter baumannii | - |
pyrazinoic acid + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Acinetobacter baumannii | B0VA03 | gene pncA | - |
Streptococcus pneumoniae | A0A0H2UR34 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
nicotinamide + H2O | - |
Streptococcus pneumoniae | nicotinate + NH3 | - |
? | |
nicotinamide + H2O | - |
Acinetobacter baumannii | nicotinate + NH3 | - |
? | |
nicotinamide + H2O | binding structure and unbinding mechanism, modeling, overview | Streptococcus pneumoniae | nicotinate + NH3 | - |
? | |
nicotinamide + H2O | binding structure involving residues A155, C159, and Ile154, and unbinding mechanism, modeling, overview | Acinetobacter baumannii | nicotinate + NH3 | - |
? | |
pyrazinamide + H2O | - |
Streptococcus pneumoniae | pyrazinoic acid + NH3 | - |
? | |
pyrazinamide + H2O | - |
Acinetobacter baumannii | pyrazinoic acid + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
nicotinamidase/pyrazinamidase | - |
Acinetobacter baumannii |
PncA | - |
Acinetobacter baumannii |
pyrazinamidase | - |
Acinetobacter baumannii |
PZAse | - |
Acinetobacter baumannii |
General Information | Comment | Organism |
---|---|---|
additional information | protein conformational changes after ligand dissociation, molecular dynamics simulation methods are performed to investigate the unbinding process of nicotinamide using the enzyme's crystal structure, PDB ID 3O94, the C136S mutation in 3O94 is restored to the wild-type Cys residue | Streptococcus pneumoniae |
additional information | protein conformational changes after ligand dissociation, molecular dynamics simulation methods are performed to investigate the unbinding process of nicotinamide using the enzyme's crystal structure. PDB ID 2WT9 | Acinetobacter baumannii |