Protein Variants | Comment | Organism |
---|---|---|
additional information | a gene disruption PncA mutant, a nicotinamidase/pyrazinamidase mutant, fails to replicate in HeLa cells and shows lower replication rates compared to the wild-type in macrophages, the mutant does not co-localize with host late endosomes or lysosomes, effects of gene disruption in vivo and in vitro, overview | Brucella abortus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
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Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
nicotinamide + H2O | Brucella abortus | contributes to the intracellular replication and infectivity of Brucella abortus in mice | nicotinate + NH3 | - |
? | |
nicotinamide + H2O | Brucella abortus 544 / ATCC 23448 | contributes to the intracellular replication and infectivity of Brucella abortus in mice | nicotinate + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Brucella abortus | - |
gene pncA, a facultative intracellular pathogen | - |
Brucella abortus 544 / ATCC 23448 | - |
gene pncA, a facultative intracellular pathogen | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | the pathogen is cultured in human HeLa cells and in murine bone marrow macrophages, co-localizes with host late endosomes or lysosomes | Brucella abortus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
nicotinamide + H2O | - |
Brucella abortus | nicotinate + NH3 | - |
? | |
nicotinamide + H2O | contributes to the intracellular replication and infectivity of Brucella abortus in mice | Brucella abortus | nicotinate + NH3 | - |
? | |
nicotinamide + H2O | - |
Brucella abortus 544 / ATCC 23448 | nicotinate + NH3 | - |
? | |
nicotinamide + H2O | contributes to the intracellular replication and infectivity of Brucella abortus in mice | Brucella abortus 544 / ATCC 23448 | nicotinate + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PncA | - |
Brucella abortus |