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Literature summary for 3.5.1.18 extracted from
- In silico approach towards identification of potential inhibitors of Helicobacter pylori DapE (2015), J. Biomol. Struct. Dyn., 33, 1460-1473 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | Tanimoto-based similarity searching in the PubChem Database with DapE substrate N-succinyl-LL-2,6-diaminoheptanedioate as a query molecule, followed by fragment-based docking approach using GLIDE XP identifies two potential substrate-competitive small molecule inhibitors of DapE. These new molecules may provide a starting point to search for novel therapeutics | Helicobacter pylori |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Helicobacter pylori | O25002 | - |
- |
| Helicobacter pylori ATCC 700392 | O25002 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DapE | - |
Helicobacter pylori |
| N-succinyl-L,L-diaminopimelic acid desuccinylase | - |
Helicobacter pylori |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | deletion of the DapE gene is lethal to Helicobacter pylori, since the organism has no alternative pathway for lysine biosynthesis | Helicobacter pylori |
| physiological function | critical enzyme of the lysine biosynthetic pathway | Helicobacter pylori |
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