Protein Variants | Comment | Organism |
---|---|---|
additional information | knockout of aspartoacylase activity leads to sponginess and loss of white matter in Canavan disease, and to increased expression/activity of cdk2, NCAM, nestin, vimentin, and NG2. Differentiation of neuronal progenitor cells is arrested, phenotype, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
nucleus | - |
Mus musculus | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | expression of full-length ASPA at embryonic day 12.5, when oligodendrocyte progenitors first appear during development | Mus musculus | - |
cerebral white matter | - |
Mus musculus | - |
oligodendrocyte | ASPA is an oligodendrocyte-specific enzyme, most active in immature oligodendrocytes | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
ASPA | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
additional information | lack of aspartoacylase activity disrupts survival and differentiation of neural progenitors and oligodendrocytes in a mouse model of Canavan disease. ASPA knockout leads to degeneration of white matter | Mus musculus |