Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Rattus norvegicus |
expression in Escherichia coli | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
resolution 1.8 angstrom | Rattus norvegicus |
resolution 2.8 Angstrom | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | necessary for activity | Rattus norvegicus | |
Zn2+ | necessary for activity, coordinated by residues His-21, Glu-24, and His-116 and a phosphate | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-L-aspartate + H2O | Rattus norvegicus | deficiency in enzyme activity leads to spongiform degeneration of the white matter of the brain and is the established cause of Canavan disease | aspartate + acetate | - |
? | |
N-acetyl-L-aspartate + H2O | Homo sapiens | deficiency in enzyme activity leads to spongiform degeneration of the white matter of the brain and is the established cause of Canavan disease | aspartate + acetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P45381 | - |
- |
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
brain | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-L-aspartate + H2O | deficiency in enzyme activity leads to spongiform degeneration of the white matter of the brain and is the established cause of Canavan disease | Rattus norvegicus | aspartate + acetate | - |
? | |
N-acetyl-L-aspartate + H2O | deficiency in enzyme activity leads to spongiform degeneration of the white matter of the brain and is the established cause of Canavan disease | Homo sapiens | aspartate + acetate | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | - |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
aminoacylase 2 | - |
Rattus norvegicus |
aminoacylase 2 | - |
Homo sapiens |
ASPA | - |
Rattus norvegicus |
ASPA | - |
Homo sapiens |
Aspartoacylase | - |
Rattus norvegicus |
Aspartoacylase | - |
Homo sapiens |