Literature summary for 3.5.1.15 extracted from

Di Pietro, V.; Gambacurta, A.; Amorini, A.M.; Finocchiaro, A.; DUrso, S.; Ceccarelli, L.; Tavazzi, B.; Giardina, B.; Lazzarino, G.
A new T677C mutation of the aspartoacylase gene encodes for a protein with no enzymatic activity (2008), Clin. Biochem., 41, 611-615.

Search for more literature for 3.5.1.15

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
2.8 angstrom resolution	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
I226T	mutant shows no catalytic activity, mutation may be responsible in homozygosis for the phenotype corresponding to Canavan disease.	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.163	-	N-acetylaspartate	-	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	essential for activity	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
36000	-	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
N-acetylaspartate + H2O	Homo sapiens	-	aspartate + acetate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
affinity chromatography	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-acetylaspartate + H2O	-	Homo sapiens	aspartate + acetate	-	?

Subunits

Subunits	Comment	Organism
homodimer	-	Homo sapiens

Synonyms

Synonyms	Comment	Organism
hASPA	-	Homo sapiens
N-acetylaspartocylase	-	Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
37.5	-	N-acetylaspartate	-	Homo sapiens

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Release 2023.1 (January 2023)