Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.1.14 extracted from

  • Shi, H.; Hayes, M.T.; Kirana, C.; Miller, R.J.; Keating, J.P.; Stubbs, R.S.
    Overexpression of aminoacylase 1 is associated with colorectal cancer progression (2013), Hum. Pathol., 44, 1089-1097.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information enzyme expression silencing in HCT-116 cells using a small interfering RNA Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q03154
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colorectal cancer cell enzyme overexpression Homo sapiens
-
epithelial cell neoplastic Homo sapiens
-
HCT-116 cell
-
Homo sapiens
-
additional information enzyme expression patterns in tumor cells, overview. No expression in stroma cells Homo sapiens
-

Synonyms

Synonyms Comment Organism
Acy1
-
Homo sapiens
aminoacylase 1
-
Homo sapiens

General Information

General Information Comment Organism
malfunction overexpression of aminoacylase 1 is associated with colorectal cancer progression. Enzyme knockdown inhibits cell proliferation and causes cell cycle perturbation Homo sapiens
additional information strong ACY1 immunoreactivity is an adverse prognostic indicator compared with combined negative and weak ACY 1 expression Homo sapiens
physiological function the enzyme is responsible for amino acid deacylation during intracellular protein degradation, it is implicated in a number of human tumor types. Strong expression of the enzyme is significantly associated with more advanced TNM stage, lymph node metastasis, positive vascular invasion, and shorter cancer-specific survival Homo sapiens