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Literature summary for 3.5.1.14 extracted from
- Aminoacylase 1 is a sphingosine kinase 1-interacting protein (2004), FEBS Lett., 568, 30-34.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| cloning of Acy1 from a mouse kidney library, expression of the C-terminal fragment in HEK-293 cells, in vitro expression of the GST-tagged C-terminal fragment, expression as myc-tagged enzyme in Cos-7 cells, expression with murine sphingosine kinase type 1, SphK1, in a yeast two-hybrid system | Mus musculus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | metalloenzyme | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | the enzyme is involved in the regulation of oxidative stress, and, by direct interaction, of sphingosine kinase type 1, SphK1, which has a role in cell growth promotion and inhibition of tumor cell apoptosis, Acy1 induces redistribution of SphK1 to the plasma membrane from cytosol, overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant GST-tagged C-terminal fragment from an in vitro expression system by glutathione affinity chromatography | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme is involved in the regulation of oxidative stress, and, by direct interaction, of sphingosine kinase type 1, SphK1, which has a role in cell growth promotion and inhibition of tumor cell apoptosis, Acy1 induces redistribution of SphK1 to the plasma membrane from cytosol, overview | Mus musculus | ? | - |
? | |
| additional information | the enzyme interacts with sphingosine kinase type 1, SphK1 | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Acy1 | - |
Mus musculus |
| aminoacylase 1 | - |
Mus musculus |
| sphingosine kinase 1-interacting protein | - |
Mus musculus |
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