Literature summary for 3.5.1.11 extracted from

Jager, S.A.; Jekel, P.A.; Janssen, D.B.
Hybrid penicillin acylases with improved properties for synthesis of beta -lactam antibiotics (2007), Enzyme Microb. Technol., 40, 1335-1344.

No PubMed abstract available

Search for more literature for 3.5.1.11

Protein Variants

Protein Variants	Comment	Organism
additional information	construction hybrids of the penicillin acylase-encoding genes from Eacherichia coli and Kluyvera cryocrescens, with additional point mutations. The hybrid enzymes display a 40-90% increase in the relative rate of acyl transfer to the beta-lactam nucleus during ampicillin synthesis. This increase is not accompanied by a reduction of synthetic activity. Similar improvements in acyl transfer are obtained for the synthesis of amoxicillin, cephalexin and cefadroxil making the new hybrid enzymes interesting candidates for the biocatalytic synthesis of several beta-lactam antibiotics	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P06875	-	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)